Magnesium-based biodegradable metals (BMs) as bone implants have better mechanical properties than biodegradable polymers, yet their strength is roughly less than 350 MPa. In this work, binary Zn alloys with alloying elements Mg, Ca, Sr, Li, Mn, Fe, Cu, and Ag respectively, are screened systemically by in vitro and in vivo studies. Li exhibits the most effective strengthening role in Zn, followed by Mg. Alloying leads to accelerated degradation, but adequate mechanical integrity can be expected for Zn alloys when considering bone fracture healing. Adding elements Mg, Ca, Sr and Li into Zn can improve the cytocompatibility, osteogenesis, and osseointegration. Further optimization of the ternary Zn-Li alloy system results in Zn-0.8Li-0.4Mg alloy with the ultimate tensile strength 646.69 ± 12.79 MPa and Zn-0.8Li-0.8Mn alloy with elongation 103.27 ± 20%. In summary, biocompatible Zn-based BMs with strength close to pure Ti are promising candidates in orthopedics for load-bearing applications.

中文翻译：

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可生物降解锌的合金设计，作为有前途的负重植入物。

作为骨植入物的镁基生物可降解金属（BMs）的机械性能优于生物可降解聚合物，但其强度大约低于350 MPa。在这项工作中，通过体外和体内研究系统地筛选了分别具有合金元素Mg，Ca，Sr，Li，Mn，Fe，Cu和Ag的二元Zn合金。Li在Zn中表现出最有效的强化作用，其次是Mg​​。合金化会加速降解，但是在考虑骨折愈合时，可以期望锌合金具有足够的机械完整性。在锌中添加元素Mg，Ca，Sr和Li可改善细胞相容性，成骨作用和骨整合。进一步优化三元Zn-Li合金系统可得到极限抗拉强度为646.69±12.79 MPa的Zn-0.8Li-0.4Mg合金和延伸率为103的Zn-0.8Li-0.8Mn合金。27±20％。总而言之，强度接近于纯钛的生物相容性锌基BMs在骨科用于承重应用中很有希望。