Design and synthesis of diethyl(substituted 2‐benzylbenzofuran‐3‐yl)phosphonates as antioxidant and antimicrobial agents,Journal of Heterocyclic Chemistry

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Design and synthesis of diethyl(substituted 2‐benzylbenzofuran‐3‐yl)phosphonates as antioxidant and antimicrobial agents
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-01-21 , DOI: 10.1002/jhet.3877
Mohan Gundluru _{1,

2} , Santhisudha Sarva ₁ , Murali Sudileti ₁ , Sreekanth Tellamekala ₁ , Subba Rao Yakkate ₂ , Bakthavatchala Reddy Nemallapudi ₃ , Suresh Reddy Cirandur ₁

Affiliation

In continuance of our effort to improve novel and potent synthetic approaches for various bioactive phosphorylated heterocycles via C─P bond formation, a series of diethyl substituted(2‐benzylbenzofuran‐3‐yl)phosphonate derivatives (4a‐j) was synthesized by one‐pot reaction of various diversely substituted salicylaldehydes, phenyl acetylene, and diethyl phosphite using CuO nanoparticles as catalyst in 1:1 ethanol and water under room temperature. The new compounds have been studied for their radical scavenging activity by DPPH, H₂O₂, and NO approaches and antimicrobial activity assay against bacteria and fungi by disk diffusion method.

中文翻译：

（乙基-2-取代的苯并呋喃-3-基）膦酸二乙酯作为抗氧化剂和抗菌剂的设计与合成

在我们的努力来提高新颖的和有效的合成的继续关于各种生物活性接近磷酸化的经由C─P键形成杂环，一系列二取代的（2-benzylbenzofuran -3-基）膦酸衍生物（的4A - Ĵ）由单合成在室温下，以1：1乙醇和水中的CuO纳米粒子为催化剂，对各种不同取代的水杨醛，苯基乙炔和亚磷酸二乙酯进行罐式反应。通过DPPH，H ₂ O ₂和NO方法研究了这些新化合物的自由基清除活性，并通过圆盘扩散法研究了它们对细菌和真菌的抗菌活性。

更新日期：2020-01-22

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