We read with great interest the paper by Hanly et al (1) discussing lupus-associated psychosis. The authors present data from the largest prospective inception cohort study to date (Systemic Lupus International Collaborating Clinics (SLICC) Cohort), which demonstrate that psychosis is a relatively rare event, occurring in 1.53% of all NPSLE patients. Of these patients with lupus-associated psychosis, almost a quarter occurred a year prior to the diagnosis of lupus, and over 80% resolved within a year. While this might suggest a benign course for psychosis, each episode of psychosis is a severe organ threatening manifestation of SLE and should be treated with immunosuppressant medications.

中文翻译：

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狼疮性精神病的四例：评论Hanly等人的文章。

我们非常感兴趣地阅读了Hanly等人（1）讨论狼疮相关性精神病的论文。作者介绍了迄今为止最大的前瞻性队列研究（系统性红斑狼疮国际合作诊所（SLICC）队列）的数据，该数据表明精神病是一种相对罕见的事件，占所有NPSLE患者的1.53％。在这些患有狼疮相关性精神病的患者中，近四分之一发生在诊断为狼疮之前一年，并且超过80％的患者在一年内得到了解决。虽然这可能暗示精神病的良性病程，但每次精神病发作都是严重的器官威胁性SLE表现，应使用免疫抑制剂治疗。