Juvenile case with the coexistence of maturity-onset diabetes of the young 1 and later-onset latent autoimmune diabetes in youth.,Journal of Diabetes Investigation

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Juvenile case with the coexistence of maturity-onset diabetes of the young 1 and later-onset latent autoimmune diabetes in youth.
Journal of Diabetes Investigation ( IF 3.1 ) Pub Date : 2020-02-20 , DOI: 10.1111/jdi.13215
Kei Yoshida ₁ , Tatsuhiko Urakami ₁ , Yusuke Mine ₁ , Remi Kuwabara ₁ , Ichiro Morioka ₁

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We present the case of a 12‐year‐old Japanese girl, who was positive for markers of both maturity‐onset diabetes of the young and latent autoimmune diabetes in youth. She was initially diagnosed with maturity‐onset diabetes of the young 1 based on the molecular analysis, and she later developed an autoimmune response, leading to β‐cell‐associated antibody‐positive diabetes. She was treated with incretin‐associated drugs and maintained adequate glycemic control. Pathophysiologically, there was an overlap between the two different types of diabetes, because the hyperglycemia and β‐cell stress seen in non‐autoimmune diabetes can cause β‐cell autoimmunity over time.

中文翻译：

青少年病例，同时存在青少年成年发病糖尿病1和青少年晚发隐性自身免疫性糖尿病。

我们介绍了一名 12 岁日本女孩的病例，她的青少年发病型糖尿病和青少年潜伏性自身免疫性糖尿病的标记物均呈阳性。根据分子分析，她最初被诊断为青少年发病的成人糖尿病，后来她出现了自身免疫反应，导致β细胞相关抗体阳性糖尿病。她接受了肠促胰岛素相关药物治疗并保持了足够的血糖控制。从病理生理学角度来看，两种不同类型的糖尿病之间存在重叠，因为非自身免疫性糖尿病中出现的高血糖和β细胞应激随着时间的推移会导致β细胞自身免疫。

更新日期：2020-02-20

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