Graphene, an allotrope of carbon, consists of a single layer of carbon atoms with uniquely tuneable properties. As such, graphene-based materials (GBMs) have gained interest for tissue engineering applications. GBMs are often discussed in the context of how different physicochemical properties affect cell physiology, without explicitly considering the impact of adsorbed proteins. Establishing a relationship between graphene properties, adsorbed proteins, and cell response is necessary as these proteins provide the surface upon which cells attach and grow. This review highlights the molecular adsorption of proteins on different GBMs, protein structural changes, and the connection to cellular function.

石墨烯是碳的同素异形体，由具有独特可调特性的单层碳原子组成。因此，石墨烯基材料（GBM）在组织工程应用中引起了人们的兴趣。人们经常在不同的理化特性如何影响细胞生理学的背景下讨论 GBM，而没有明确考虑吸附蛋白质的影响。建立石墨烯特性、吸附蛋白质和细胞反应之间的关系是必要的，因为这些蛋白质提供了细胞附着和生长的表面。这篇综述重点介绍了不同 GBM 上蛋白质的分子吸附、蛋白质结构变化以及与细胞功能的联系。