Perfluoroalkyl acids (PFAAs) are man-made organic pollutants that are found ubiquitously in the environment and may impact human health. Here, we review the published literature concerning PFAA impacts on neurobiological, neuroendocrine, and neurobehavioral outcomes. We find that there are many mechanisms through which PFAAs may enter the brain and interact with biochemical endpoints to impact neurological function. These results are supported by epidemiological evidence in humans and experimental evidence in animals that demonstrate numerous and varied PFAA impacts on the nervous system. However, the methods commonly used in animal models of PFAA exposure result in durations of exposure and serum PFAA concentrations in blood that may not appropriately mimic human absorption, distribution, metabolism, and excretion. If animal models lack validity, confidence in mechanistic inferences regarding PFAA exposure and brain function is reduced, limiting these studies' utility. Finally, we end by suggesting some potential impacts of PFAA exposure in human neurological health and disease states whose associations may not readily present themselves in the epidemiological literature.

中文翻译：

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神经系统健康和疾病中的全氟烷基化学品：人类关注和动物模型。

全氟烷基酸（PFAAs）是人为的有机污染物，在环境中普遍存在，并可能影响人体健康。在这里，我们回顾了有关PFAA对神经生物学，神经内分泌和神经行为结果的影响的已发表文献。我们发现，PFAA可能通过许多机制进入大脑并与生化终点相互作用以影响神经功能。这些结果得到了人类流行病学证据和动物实验证据的支持，这些证据表明PFAA对神经系统的影响多种多样。但是，通常在动物PFAA暴露模型中使用的方法会导致暴露持续时间和血液中的血清PFAA浓度无法适当地模拟人的吸收，分布，代谢和排泄。如果动物模型缺乏有效性，关于PFAA暴露和脑功能的机械推断的信心降低，从而限制了这些研究的实用性。最后，我们最后提出了PFAA暴露对人类神经系统健康和疾病状态的某些潜在影响，这些疾病的关联在流行病学文献中可能并不容易展现出来。