3D printing of polylactic acid (PLA) and hydroxyapatite (HA) or bioglass (BG) bioceramics composites is the most promising technique for artificial bone construction. However, HA and BG have different chemical composition as well as different bone regeneration inducing mechanisms. Thus, it is important to compare differentiation processes induced by 3D printed PLA + HA and PLA + BG scaffolds in order to evaluate the strongest osteoconductive and osteoinductive properties possessing bioceramics. In this study, we analysed porous PLA + HA (10%) and PLA + BG (10%) composites' effect on rat's dental pulp stem cells fate in vitro. Obtained results indicated, that PLA + BG scaffolds lead to weaker cell adhesion and proliferation than PLA + HA. Nevertheless, osteoinductive and other biofriendly properties were more pronounced by PLA + BG composites. Overall, the results showed a strong advantage of bioceramic BG against HA, thus, 3D printed PLA + BG composite scaffolds could be a perspective component for patient-specific, cheaper and faster artificial bone tissue production.

聚乳酸（PLA）和羟基磷灰石（HA）或生物玻璃（BG）生物陶瓷复合材料的3D打印是用于人造骨构造的最有希望的技术。然而，HA和BG具有不同的化学组成以及不同的骨再生诱导机制。因此，重要的是比较3D打印的PLA + HA和PLA + BG支架诱导的分化过程，以评估生物陶瓷所具有的最强的骨传导性和骨诱导性。在这项研究中，我们分析了多孔PLA + HA（10％）和PLA + BG（10％）复合材料对大鼠牙髓干细胞体外命运的影响。所得结果表明，PLA + BG支架比PLA + HA导致细胞粘附和增殖能力弱。然而，PLA + BG复合材料更明显地具有骨诱导性和其他生物友好性。总体而言，结果显示生物陶瓷BG相对于HA具有强大的优势，因此3D打印的PLA + BG复合支架可以成为患者特定，更便宜和更快的人工骨组织生产的一种视角组件。