当前位置: X-MOL 学术Gastrointest. Endosc. › 论文详情
Short-term outcomes of double pyloromyotomy versus single pyloromyotomy at peroral endoscopic pyloromyotomy in treatment of gastroparesis (with video)
Gastrointestinal Endoscopy ( IF 7.229 ) Pub Date : 2020-01-17 , DOI: 10.1016/j.gie.2020.01.016
Mohamed M. Abdelfatah; Baiwen Li; Neil Kapil; Alan Noll; Lianyong Li; Hui Luo; Huimin Chen; Liang Xia; Xiangbo Chen; Vailshali Patel; Parit Mekaroonkamol; Julia Massaad; Steven Keilin; Qiang Cai

Background and Aims Gastroparesis (Gp) is a chronic debilitating disorder rising in prevalence and hospitalizations. Gastric peroral endoscopic pyloromyotomy (POP or GPOEM) is a novel technique in the treatment of refractory Gp. Despite the initial promising results of GPOEM, one-third of patients do not exhibit any clinical response. Furthermore, loss of clinical response was reported in several studies. No response or loss of response after GPOEM may be related to inadequate myotomy. The aim of our study is to examine whether double pyloromyotomy at GPOEM is superior to single pyloromyotomy. Method A retrospective case-controlled study of patients who underwent GPOEM for refractory Gp at our tertiary care institution between June 2015 and March 2018 was performed. Because the follow-up time for the single myotomy group was much longer than that of the double-myotomy group, we matched the length of follow-up for the single myotomy group to that of the double myotomy group. The outcomes were measured by the changes in Gp cardinal symptom index (GCSI) before and 3 to 6 months after the procedure. Adverse events and other procedural and clinical parameters were also compared. Results Ninety patients underwent GPOEM (55 single and 35 double pyloromyotomy) Mean age was 47 ±14 years old, mean duration of symptoms was 5.3 ± 4.4 years. Average GCSI was 3.8 before the GPOEM and the average GCSI 6 months after procedure was 1.8 37 out of 55 (67%) patients underwent single pyloromyotomy achieved clinical response compared with 30 out of 35 (86%) patients receiving double pyloromyotomy. There were no significant differences among procedure time, postoperative pain or length of hospital stay between the 2 groups. There was no difference in adverse events in the 2 pyloromyotomy groups. Conclusion Double pyloromyotomy is a safe and feasible technique during GPOEM. Clinical success was higher in patients undergoing double pyloromyotomy compared with single pyloromyotomy in this nonrandomized, short-term follow-up study. Long-term studies are needed to further confirm our results.
更新日期:2020-01-21

 

全部期刊列表>>
化学/材料学中国作者研究精选
ACS材料视界
南京大学
自然科研论文编辑服务
剑桥大学-
中国科学院大学化学科学学院
南开大学化学院周其林
课题组网站
X-MOL
北京大学分子工程苏南研究院
华东师范大学分子机器及功能材料
中山大学化学工程与技术学院
试剂库存
天合科研
down
wechat
bug