Abstract An electrochemical sensor is described for the determination of nadifloxacin (NF). A glassy carbon electrode (GCE) was modified with amino-functionalized multiwalled carbon nanotubes and titanium dioxide nanoparticles. The modified GCE was characterized by electrochemical impedance spectroscopy, cyclic voltammetry and scanning electron microscopy. The electro-oxidation of NF follows a pH-dependent irreversible behavior. The effects of pH value, scan rate, supporting electrolyte, accumulation potential and accumulation time were optimized. Under optimum conditions and at a typical working potential of 600 mV (vs. Ag/AgCl), the adsorptive stripping voltammetric response is linear in the 5 nM to 5.0 μM NF concentration range. The limit of detection is 1.69 × 10−10 M in acidic solution of pH 1. The selectivity was investigated in the presence of 1–1000-fold concentrations of potentially interfering agents. Recoveries from cream formulations spiked with NF were performed to study precision and accuracy.

中文翻译：

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基于NH2-fMWCNT-二氧化钛纳米复合材料的电化学传感器，用于抗生素药物那氟沙星的伏安分析及其体外渗透研究

摘要 描述了一种用于测定那氟沙星 (NF) 的电化学传感器。用氨基功能化的多壁碳纳米管和二氧化钛纳米粒子修饰玻碳电极 (GCE)。修改后的 GCE 通过电化学阻抗谱、循环伏安法和扫描电子显微镜进行表征。NF 的电氧化遵循 pH 依赖性不可逆行为。优化了pH值、扫描速率、支持电解质、积累电位和积累时间的影响。在最佳条件和 600 mV（相对于 Ag/AgCl）的典型工作电位下，吸附溶出伏安响应在 5 nM 至 5.0 μM NF 浓度范围内呈线性。在 pH 1 的酸性溶液中，检测限为 1.69 × 10−10 M。在存在 1-1000 倍浓度的潜在干扰物质的情况下研究了选择性。对掺有 NF 的乳膏配方进行回收，以研究精密度和准确度。