Normal aging is accompanied by cognitive and memory impairments that negatively impact quality of life for the growing elderly population. Hippocampal function is most vulnerable to the deleterious effects of aging, and deficits in hippocampus-dependent memories are common amongst aged individuals. Moreover, signaling networks such as the cAMP/PKA/CREB pathway, which are critical for memory consolidation, are dampened in healthy aged subjects. Phosphodiesterase (PDE) enzymes that break down cAMP are also affected by aging, and increased break down of cAMP by PDEs may contribute to reduced activity of the cAMP/PKA/CREB signaling network in the brain of aged individuals. Here, we report that the PDE4 inhibitor rolipram administered during consolidation of hippocampus-dependent object location memory improves aged-related spatial memory deficits in aged mice.

中文翻译：

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巩固期间的咯利普兰治疗改善了老年雄性小鼠的长期物体位置记忆。

正常衰老伴随着认知和记忆障碍，对不断增长的老年人口的生活质量产生负面影响。海马功能最容易受到衰老的有害影响，海马依赖记忆的缺陷在老年人中很常见。此外，对记忆巩固至关重要的信号网络，如 cAMP/PKA/CREB ​​通路，在健康的老年受试者中受到抑制。分解 cAMP 的磷酸二酯酶 (PDE) 酶也受衰老的影响，并且 PDE 对 cAMP 的分解增加可能导致老年人大脑中 cAMP/PKA/CREB ​​信号网络的活性降低。这里，