In fixed‐dose antidepressant trials, the lower range of the licensed dose achieves the optimal balance between efficacy and tolerability. Whether flexible upward titration while side‐effects permit provides additional benefits is unknown.

中文翻译：

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在为重度抑郁症开抗抑郁药时，灵活滴定高于最低许可剂量没有益处

在固定剂量抗抑郁药试验中，许可剂量的较低范围实现了疗效和耐受性之间的最佳平衡。在副作用允许的情况下灵活的向上滴定是否提供额外的好处尚不清楚。