6‐Triphenylphosphinehexanoic Acid Conjugated Near‐Infrared Persistent Luminescence Nanoprobe for Autofluorescence‐Free Targeted Imaging of Mitochondria in Cancer Cells,ChemNanoMat

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6‐Triphenylphosphinehexanoic Acid Conjugated Near‐Infrared Persistent Luminescence Nanoprobe for Autofluorescence‐Free Targeted Imaging of Mitochondria in Cancer Cells
ChemNanoMat ( IF 2.6 ) Pub Date : 2020-02-03 , DOI: 10.1002/cnma.201900697
Yu‐Bin Su _{1,

2,

3} , Xu Zhao _{1,

2,

3} , Li‐Jian Chen _{1,

2,

3} , Hai‐Long Qian _{1,

2,

3} , Xiu‐Ping Yan _{1,

2,

3}

Affiliation

Mitochondria, as the energy provider for cells, play a key role in cell physiological processes. Mitochondrion‐targeted imaging is of great significance for understanding the physiological functions and pathology involved in various diseases. Herein, we report the fabrication of 6‐triphenylphosphinehexanoic acid (TPP) conjugated near‐infrared persistent luminescence nanoparticles (PLNP) (PLNP‐TPP) for mitochondria‐targeted imaging in cancer cells. The PLNP was prepared by doping Cr(III) into gallogermanate through a hydrothermal method. The as‐prepared PLNP showed small size, monodispersity, excellent near‐infrared (NIR) luminescence and visible light renewable NIR luminescence. The grafted TPP facilitated the transportation of PLNP‐TPP across the mitochondrial membrane and enabled staining of the mitochondrial region in live cancer cells. This work provides a promising strategy for fabricating PLNP nanoprobes to realize mitochondrial‐targeting bioimaging.

中文翻译：

6-三苯基膦己酸共轭近红外持久发光纳米探针，用于癌细胞中线粒体的无自发荧光靶向成像

线粒体作为细胞的能量提供者，在细胞生理过程中起着关键作用。线粒体靶向成像对于理解各种疾病涉及的生理功能和病理学具有重要意义。在此，我们报道了6-三苯基膦己酸（TPP）共轭的近红外持续发光纳米粒子（PLNP）（PLNP-TPP）的制造，用于癌细胞中线粒体靶向成像。PLNP是通过水热法将Cr（III）掺入高锰酸镓中而制得的。所制备的PLNP具有小尺寸，单分散性，出色的近红外（NIR）发光和可见光可再生NIR发光。嫁接的TPP促进了PLNP‐TPP跨线粒体膜的运输，并使活癌细胞中的线粒体区域染色。

更新日期：2020-02-03

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