Chemical analysis has long relied on instrumentation, from the simplest (eg burets) to the more sophisticated (eg mass spectrometers) to facilitate precision measurements. Regardless of their complexity, the development of a new instrumental device can be a valued approach to address problems in science. In this perspective, we outline the process of novel device design, from early phase conception to the manufacturing and testing of the tool or gadget. Focus is placed on the development of improved front-end devices to facilitate protein sample manipulations ahead of mass spectrometry, which therefore augment the proteomics workflow.. Highlighted are some of the many training secrets, choices and challenges that are inherent to the often iterative process of device design. In hopes of inspiring others to pursue instrument design to address relevant research questions, we present a summary list of points to consider prior to innovating their own devices.

中文翻译：

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开发用于改进基于MS的蛋白质组分析中样品制备的前端设备。

化学分析一直以来都依赖于仪器，从最简单的仪器（例如滴定管）到更复杂的仪器（例如质谱仪），以促进精确测量。无论其复杂性如何，开发新的仪器设备都是解决科学问题的一种有价值的方法。从这个角度出发，我们概述了新颖的设备设计过程，从早期构思到工具或小工具的制造和测试。重点放在开发改进的前端设备上，以促进在质谱分析之前进行蛋白质样品操作，从而扩大了蛋白质组学工作流程。设备设计。