Mild Palladium‐Catalyzed Cyanation of Unprotected 2‐Iodoglycals in Aqueous Media as Versatile Tool to Access Diverse C2‐Glycoanalogues,Advanced Synthesis & Catalysis

当前位置： X-MOL 学术 › Adv. Synth. Catal. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Mild Palladium‐Catalyzed Cyanation of Unprotected 2‐Iodoglycals in Aqueous Media as Versatile Tool to Access Diverse C2‐Glycoanalogues
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-01-30 , DOI: 10.1002/adsc.201901583
Maciej Malinowski _{1,

2} , Thanh Van Tran ₁ , Morgane Robichon ₁ , Nadège Lubin‐Germain ₁ , Angélique Ferry ₁

Affiliation

Access to unprotected 2‐cyano‐glycals via a mild palladium‐catalyzed cyanation of protecting groups‐free 2‐iodoglycals in aqueous media has been developed. Diverse glycal substrates including disaccharide‐type were successfully obtained in good to excellent yields. These unprotected 2‐cyano‐glycal scaffolds were successfully derivatized to different C2‐glycoanalogues.

中文翻译：

轻度钯催化水介质中未保护的2碘糖的氰化反应，作为获得各种C2糖类似物的多功能工具

已经开发了通过轻度钯催化的水性介质中不含保护基的2-碘糖的氰化反应，获得未保护的2-氰基糖的方法。包括二糖类在内的多种糖类底物均以良好至极好的收率成功获得。这些未保护的2-氰基葡萄糖支架成功衍生化为不同的C2糖醛酸类似物。

更新日期：2020-01-31

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11