Photo‐Mediated Decarboxylative Ketonization of Atropic Acids with Sulfonyl Hydrazides: Direct Access to β‐Ketosulfones,Advanced Synthesis & Catalysis

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Photo‐Mediated Decarboxylative Ketonization of Atropic Acids with Sulfonyl Hydrazides: Direct Access to β‐Ketosulfones
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-01-17 , DOI: 10.1002/adsc.201901525
Jie Chen ₁ , Zoe G. Allyson ₂ , Jing‐Rui Xin ₁ , Zhi Guan ₁ , Yan‐Hong He ₁

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An efficient formation of synthetically and biologically relevant β‐ketosulfones via a photo‐mediated decarboxylative ketonization of atropic acids was disclosed. The approach features metal‐free conditions, good functional group compatibility, readily available starting materials and the use of ubiquitous dioxygen as both oxygen source and oxidant. Furthermore, mechanistic studies reveal that the decarboxylative ketonization reaction proceeds via a radical mechanism and may involve a radical chain reaction.

中文翻译：

磺酸与酰肼的光介导的脱氢酸的脱羧酮化：直接获得β-酮砜

公开了通过无光子酸的光介导的脱羧酮化作用，有效形成合成和生物学上相关的β-酮砜的方法。该方法的特点是无金属条件，良好的官能团相容性，易于获得的原料以及使用普遍存在的双氧作为氧源和氧化剂。此外，机理研究表明，脱羧酮化反应是通过自由基机理进行的，并且可能涉及自由基链反应。

更新日期：2020-01-17

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