Cranberry (Vaccinium macrocarpon) fruits are known for their high polyphenolics content making them a rich source of antioxidants. These polyphenolics have been reported to promote human health and are gaining attention for their antimicrobial activities against foodborne pathogens. We investigated the antimicrobial activity of an ethanolic extract #(FC111-1) prepared from cranberry pomace against Listeria spp. Many polyphenolics were identified in this extract which could be responsible for growth-inhibitory effects against 12 Listeria strains including L. monocytogenes. The minimum inhibitory concentration (MIC) of #FC111-1 determined in cation-adjusted Muller Hinton broth (CAMHB) was approximately 2 mg/mL for 11 (91.7%) of these strains. The inclusion of 2–8 mg/mL (1–4 × MIC) of #FC111-1 decreased (>3 log₁₀) viable bacterial cells of all Listeria strains in CAMHB over a 24 h period, while dose-dependently reducing bacterial salt tolerance, bacterial bile-salt hydrolase activity, bacterial biofilm formation capacity, and increasing cell-membrane permeability. The #FC111-1 extract (0.4 and 0.8% concentrations) had no effect on L. monocytogenes survival in a cooked chicken-breast meat model, highlighting the influence of protein-rich matrices on antibacterial activity and the need to consider the role of food composition when using extracts or polyphenolics from cranberry fruits to improve food-safety.

蔓越莓（Vaccinium macrocarpon）水果因其多酚含量高而闻名，使其成为抗氧化剂的丰富来源。据报道，这些多酚类物质可促进人类健康，并因其对食源性病原体的抗菌作用而受到关注。我们调查了从蔓越莓果渣制备的乙醇提取物＃（FC111-1）对李斯特菌的抗菌活性。在该提取物中鉴定出许多多酚类物质，它们可能对包括单核细胞增生李斯特菌在内的12种李斯特菌菌株具有抑制生长的作用。。在阳离子调节的Muller Hinton肉汤（CAMHB）中确定的＃FC111-1的最低抑制浓度（MIC）对这些菌株中的11株（91.7％）约为2 mg / mL。在24小时内，CAMHB中所有李斯特菌菌株中2-8 mg / mL（1-4×MIC）的＃FC111-1的存活细菌细胞减少（> 3 log ₁₀），同时细菌剂量呈剂量依赖性减少耐受性，细菌胆盐水解酶活性，细菌生物膜形成能力和细胞膜通透性增加。＃FC111-1提取物（0.4和0.8％的浓度）对单核细胞增生李斯特菌没有影响 在煮熟的鸡胸肉模型中的存活率，突显了富含蛋白质的基质对抗菌活性的影响，以及在使用蔓越莓果实的提取物或多酚类成分改善食品安全性时需要考虑食品成分的作用。