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Protective role of brain derived neurotrophic factor (BDNF) in obstructive sleep apnea syndrome (OSAS) patients.
PLOS ONE ( IF 2.9 ) Pub Date : 2020-01-17 , DOI: 10.1371/journal.pone.0227834 Krisstopher Richard Flores 1 , Fausta Viccaro 1 , Mauro Aquilini 1 , Stefania Scarpino 1 , Francesco Ronchetti 1 , Rita Mancini 1 , Arianna Di Napoli 1 , Davide Scozzi 2 , Alberto Ricci 1
PLOS ONE ( IF 2.9 ) Pub Date : 2020-01-17 , DOI: 10.1371/journal.pone.0227834 Krisstopher Richard Flores 1 , Fausta Viccaro 1 , Mauro Aquilini 1 , Stefania Scarpino 1 , Francesco Ronchetti 1 , Rita Mancini 1 , Arianna Di Napoli 1 , Davide Scozzi 2 , Alberto Ricci 1
Affiliation
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Obstructive sleep apnea syndrome (OSAS) is a common disorder characterized by repeated episodes of upper airways collapse during the sleep. The following intermittent hypoxia triggers a state of chronic inflammation, which also interests the nervous system leading to neuronal damage and increased risk of cognitive impairment. Brain derived neurotrophic factor (BDNF) is a growth factor often associated with neuroplasticity and neuroprotection whose levels increase in several condition associated with neuronal damage. However, whether patients affected by OSAS have altered BDNF levels and whether such alteration may be reflective of their cognitive impairment is still controversial. Here we show that, when compared to healthy control volunteers, OSAS patients have increased serum levels of BDNF. Moreover, OSAS patients with the higher levels of BDNF also have reduced neurocognitive impairment as measured by The Montreal Cognitive Assessment (MoCA) questionnaire. Treatment with standard non-invasive mechanical ventilation (CPAP) also was able to ameliorate the level of cognitive impairment. Altogether our results indicate that BDNF levels represent a neuroprotective response to intermittent hypoxia in OSAS patients.
中文翻译：
脑源性神经营养因子（BDNF）在阻塞性睡眠呼吸暂停综合症（OSAS）患者中的保护作用。
阻塞性睡眠呼吸暂停综合症（OSAS）是一种常见的疾病，其特征是睡眠期间上呼吸道反复发作。接下来的间歇性缺氧会触发慢性炎症状态，这也会引起神经系统的损伤，从而导致神经元损伤和认知障碍的风险增加。脑源性神经营养因子（BDNF）是通常与神经可塑性和神经保护相关的生长因子，其水平在几种与神经元损伤相关的疾病中会增加。然而，受OSAS影响的患者是否已经改变了BDNF水平，以及这种改变是否可能反映出他们的认知障碍仍存在争议。在这里，我们表明，与健康对照志愿者相比，OSAS患者的BDNF血清水平升高。此外，根据蒙特利尔认知评估（MoCA）调查表，具有较高BDNF水平的OSAS患者的神经认知障碍也有所减少。标准无创机械通气（CPAP）的治疗也能够改善认知障碍的水平。总的来说，我们的结果表明BDNF水平代表OSAS患者对间歇性缺氧的神经保护反应。
更新日期：2020-01-21
中文翻译：
脑源性神经营养因子（BDNF）在阻塞性睡眠呼吸暂停综合症（OSAS）患者中的保护作用。
阻塞性睡眠呼吸暂停综合症（OSAS）是一种常见的疾病，其特征是睡眠期间上呼吸道反复发作。接下来的间歇性缺氧会触发慢性炎症状态，这也会引起神经系统的损伤，从而导致神经元损伤和认知障碍的风险增加。脑源性神经营养因子（BDNF）是通常与神经可塑性和神经保护相关的生长因子，其水平在几种与神经元损伤相关的疾病中会增加。然而，受OSAS影响的患者是否已经改变了BDNF水平，以及这种改变是否可能反映出他们的认知障碍仍存在争议。在这里，我们表明，与健康对照志愿者相比，OSAS患者的BDNF血清水平升高。此外，根据蒙特利尔认知评估（MoCA）调查表，具有较高BDNF水平的OSAS患者的神经认知障碍也有所减少。标准无创机械通气（CPAP）的治疗也能够改善认知障碍的水平。总的来说，我们的结果表明BDNF水平代表OSAS患者对间歇性缺氧的神经保护反应。
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