Abstract Plants maintain cellular proteostasis during different phases of growth and development despite a barrage of biotic and abiotic stressors in an ever-changing environment. This requires a collaborative effort of a cadre of molecular chaperones. Hsp70s and their obligate co-chaperones, J-domain proteins (JDPs), are arguably the most ubiquitous and formidable components of the cellular chaperone network, facilitating numerous and diverse cellular processes and allowing survival under a plethora of stressful conditions. JDPs are also among the most versatile chaperones. Compared to Hsp70s, the number of JDP-encoding genes has proliferated, suggesting the emergence of highly complex Hsp70-JDP networks, particularly in plants. Recent studies indicate that besides the increase in the number of JDP encoding genes; regulatory differences, neo- and sub-functionalization, and inter- and intra-class combinatorial interactions, is rapidly expanding the repertoire of Hsp70-JDP systems. This results in highly robust and functionally diverse chaperone networks in plants. Here, we review the current status of plant JDP research and discuss how the paradigm shift in the field can be exploited toward a better understanding of JDP function and evolution.

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不断扩大的植物 J 域蛋白世界

摘要 尽管在不断变化的环境中存在大量生物和非生物压力因素，植物在生长和发育的不同阶段仍保持细胞蛋白质稳态。这需要分子伴侣的共同努力。Hsp70 及其专性共伴侣 J 域蛋白 (JDP) 可以说是细胞伴侣网络中最普遍和最强大的组成部分，促进了众多多样的细胞过程，并允许在过多的压力条件下生存。JDP 也是最通用的伴侣之一。与 Hsp70 相比，JDP 编码基因的数量激增，表明出现了高度复杂的 Hsp70-JDP 网络，尤其是在植物中。最近的研究表明，除了 JDP 编码基因数量的增加；监管差异，新功能和子功能化以及类间和类内组合相互作用正在迅速扩展 Hsp70-JDP 系统的所有功能。这导致植物中高度稳健且功能多样的伴侣网络。在这里，我们回顾了植物 JDP 研究的现状，并讨论了如何利用该领域的范式转变来更好地理解 JDP 的功能和进化。