BACKGROUND To examine the incidence of atrial fibrillation in individuals with type 2 diabetes compared with age- and sex-matched controls from the general population and its variation in relation to glycaemic control and renal function. METHODS A total of 421,855 patients with type 2 diabetes from the Swedish National Diabetes Registry and 2,131,223 controls from the Swedish Population Registry, matched for age, sex and county, were included and followed from January 1, 2001 to December 31, 2013. RESULTS Overall, 8.9% of individuals with type 2 diabetes and 7.0% of controls were diagnosed with atrial fibrillation during follow-up, unadjusted incidence risk ratio (IRR) 1.35 (95% 1.33-1.36). Women < 55 years old with type 2 diabetes had an IRR of 2.36 (95% CI 2.10-2.66), in relation to controls, whereas the corresponding value for men < 55 years old with type 2 diabetes was IRR 1.78 (95% CI 1.67-1.90). In the fully adjusted Cox regression, the risk of type 2 diabetes on incident atrial fibrillation was 28% greater vs controls, hazard ratio (HR) 1.28 (95% CI 1.26-1.30), p < 0.0001. The excess risk of atrial fibrillation in individuals with type 2 diabetes increased with worsening glycaemic control and renal complications. For individuals with HbA1c ≤ 6.9% (≤ 52 mmol/mol) and normoalbuminuria the excess risk vs controls was still increased, adjusted HR 1.16 (95% CI 1.14-1.19); p < 0.0001. CONCLUSIONS Individuals with type 2 diabetes had an overall 35% higher risk of atrial fibrillation compared to age- and sex-matched controls from the general population. The excess risk for atrial fibrillation increased with renal complications or with poor glycaemic control. Individuals with type 2 diabetes with good glycaemic control and normoalbuminuria had slightly increased risk.

中文翻译：

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瑞典一项队列研究显示，患有2型糖尿病的人发生房颤的风险以及与血糖控制和肾功能有关的过度风险。

背景技术与普通人群中年龄和性别相匹配的对照相比，研究2型糖尿病患者心房颤动的发生率及其在血糖控制和肾功能方面的变化。方法纳入2001年1月1日至2013年12月31日的瑞典国家糖尿病登记处的421855名2型糖尿病患者和瑞典人口登记处的2131223例对照，按年龄，性别和县进行匹配。随访期间，有8.9％的2型糖尿病患者和7.0％的对照组被诊断为房颤，未经调整的发生风险比（IRR）为1.35（95％为1.33-1.36）。与对照组相比，<55岁的2型糖尿病女性的IRR为2.36（95％CI 2.10-2.66），而男性的相应值为< 55岁的2型糖尿病患者的IRR为1.78（95％CI 1.67-1.90）。在完全调整的Cox回归中，发生心房纤颤的2型糖尿病风险比对照组高28％，风险比（HR）1.28（95％CI 1.26-1.30），p <0.0001。2型糖尿病患者发生房颤的额外风险随着血糖控制和肾脏并发症的恶化而增加。对于HbA1c≤6.9％（≤52 mmol / mol）和正常白蛋白尿的个体，与对照组相比，过高的风险仍然增加，调整后的HR为1.16（95％CI 1.14-1.19）。p ＜0.0001。结论与一般人群中年龄和性别相匹配的对照组相比，2型糖尿病患者的房颤总体风险高35％。肾并发症或血糖控制不良会增加房颤的额外风险。