BACKGROUND Uric acid has been identified as an important factor in the development of hypertension. If low birth weight (LBW) combined with catch-up growth (CUG) is associated with continuously elevated serum uric acid levels (SUA) level trajectories, LBW children who experience CUG may have an increased risk of hypertension later in life. Therefore, this cohort study analyzed longitudinal trends in SUA levels and changes in blood pressure in relation to pre- and postnatal growth over an extended follow-up period. METHODS This prospective cohort study of 364 children from the Ewha Birth and Growth Cohort assessed the effects of pre- and postnatal growth status on SUA at 3, 5, and 7 years of age using a linear mixed model and the change in blood pressure over the 7-year follow-up period using a generalized linear model (analysis of covariance). CUG was defined as a change in weight (between birth and age 3) with a z-score > 0.67 for LBW subjects. The multivariate model considered sex, gestational age, and uric acid, height, and weight at 3 years of age. RESULTS Children with LBW and CUG had higher SUA for the first 7 years of life compared to the normal birth weight group. This trend was particularly evident when comparing LBW children at term to children with normal birth weight. Within the group with LBW at term, children with greater CUG had higher SUA than children with normal birth weight, and this difference increased with age. Changes in the systolic blood pressure between 3 and 7 years of age were higher by 7.9 mmHg in children who experienced LBW and CUG compared with those who had a normal birth weight after adjusting for sex, gestational age, and height, weight, and uric acid at 3 years of age (p-value = 0.08). CONCLUSIONS The uric acid levels and changes in systolic blood pressure were consistently higher among LBW children who experienced CUG compared with NBW children for the first 7 years of life. LBW children who experienced greater weight gain from birth to age 3 had even higher uric acid levels compared with NBW children.

中文翻译：

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3至7岁儿童的产前和产后生长与血清尿酸水平和血压的纵向趋势之间的关联。

背景技术尿酸已经被确定为高血压发展的重要因素。如果低出生体重（LBW）和追赶性生长（CUG）伴随着血清尿酸水平（SUA）水平轨迹的持续升高，则患有CUG的LBW儿童在以后的生活中患高血压的风险可能会增加。因此，该队列研究分析了长期随访期间SUA水平的纵向趋势以及与产前和产后生长相关的血压变化。方法这项前瞻性队列研究对364名来自梨花酒（Ewha）出生和生长队列的儿童进行了评估，使用线性混合模型评估了出生前和出生后生长状况对3岁，5岁和7岁时SUA的影响以及血压的变化。使用广义线性模型（协方差分析）的7年随访期。CUG被定义为LBW受试者的体重变化（出生至3岁之间），z得分> 0.67。多元模型考虑了3岁时的性别，胎龄和尿酸，身高和体重。结果与正常出生体重组相比，LBW和CUG患儿在出生后的头7年具有较高的SUA。当比较足月出生的LBW儿童与正常出生体重的儿童时，这一趋势尤其明显。在足月LBW组中，CUG较高的儿童的SUA高于正常体重的儿童，并且这种差异随着年龄的增长而增加。调整了性别，胎龄和身高，体重后，经历LBW和CUG的儿童与正常体重的儿童相比，3至7岁之间的收缩压变化高7.9 mmHg，和3岁时的尿酸（p值= 0.08）。结论在出生后的头7年中，经历CUG的LBW儿童的尿酸水平和收缩压变化始终高于NBW儿童。从出生到3岁体重增加更大的LBW儿童比NBW儿童的尿酸水平更高。