BACKGROUND Studies on characteristic spinal deformities in Japanese patients with ankylosing spondylitis (AS) and data demonstrating a relationship between health-related quality of life (HRQOL) and spinopelvic alignment in these patients are lacking. METHODS In this cross-sectional study, 50 patients with AS and without a surgical history, vertebral body fracture, or scoliosis as well as 30 control patients with degenerative lumbar kyphoscoliosis (DLKS) were included. Data collected included patient sex, age, spinopelvic parameters on sagittal full-spine standing radiographs, and HRQOL questionnaire responses. Student's t-test was used to compare the characteristics of spinopelvic parameters between the groups. A multiple regression analysis was performed to analyze correlations between spinopelvic parameters and HRQOL in the AS group. RESULTS Global kyphosis (GK; T1-12 angle) was significantly greater in the AS group than in the DLKS group (P < 0.001), whereas the pelvic tilt (PT; posterior PT angle) was smaller in the AS group (P = 0.006). Radiographic parameters correlated with HRQOL in the AS group. Multiple regression analysis identified the sagittal vertical axis (SVA) and sacral slope (SS) as factors influencing the SRS-22 total score and SVA and GK as factors influencing Japanese Orthopaedic Association Back Pain Evaluation Questionnaire mental health (subdomain). CONCLUSIONS Patients with AS did not use lumbar lordosis or posterior PT to compensate for their large thoracic kyphosis due to spinopelvic ankylosis. These patients showed a unique compensation pattern. The correlation/regression analysis revealed a correlation between radiographic parameters and HRQOL in patients with AS, with particular importance of SVA, SS, and GK for clinical results in AS.

中文翻译：

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日本强直性脊柱炎患者脊柱骨盆排列特征与生活质量之间的关系：一项横断面研究。

背景技术缺乏对日本强直性脊柱炎（AS）患者特征性脊柱畸形的研究，以及缺乏证明这些患者健康相关生活质量（HRQOL）与脊柱盆腔对准之间关系的数据。方法在这项横断面研究中，纳入了50例没有手术史，没有椎体骨折或脊柱侧弯的AS患者以及30例退行性腰椎后凸畸形（DLKS）对照患者。收集的数据包括患者性别，年龄，矢状全脊柱站立X线照片上的脊柱骨盆参数以及HRQOL问卷答复。使用学生t检验比较两组之间脊柱骨参数的特征。进行了多元回归分析，以分析AS组脊柱骨盆参数与HRQOL之间的相关性。结果AS组的总后凸畸形（GK; T1-12角）明显大于DLKS组（P <0.001），而AS组的骨盆倾斜度（PT;后PT角）较小（P = 0.006） ）。放射学参数与AS组中的HRQOL相关。多元回归分析确定了矢状纵轴（SVA）和骨斜率（SS）是影响SRS-22总分的因素，而SVA和GK是影响日本骨科协会腰痛评估调查表心理健康的因素（子域）。结论AS患者没有使用腰椎前凸或后PT来弥补由于脊柱盆腔强直所致的大胸椎后凸畸形。这些患者表现出独特的补偿方式。