BACKGROUND Human cytomegalovirus (HCMV) seropositivity has been associated with higher inflammation during rheumatoid arthritis (RA). However, no data are available on the impact of HCMV seropositivity on bone erosion progression during RA. METHODS We selected 487 individuals of ESPOIR cohort who fulfilled the 2010 ACR/EULAR criteria for RA. HCMV serology for these patients was determined using Architect CMV IgG assay. Baseline and 1-year central X-ray reading using modified Total Sharp Score (mTSS), Erosion Sharp Score, and joint space narrowing Sharp score were used to quantify structural damage progression. We performed univariate and multivariate analyses to investigate the association between HCMV status and bone erosion progression. RESULTS We analyzed 273 HCMV seropositive (HCMV+) and 214 HCMV seronegative (HCMV-) RA patients. At inclusion, HCMV+ patients were less frequently ACPA+ (49.8% versus 58.9%, p < 0.0465) and had a higher DAS28-ESR (5.55 ± 1.24 versus 5.20 ± 1.14, p < 0.0013) in comparison with HCMV-. At 1 year, bone erosion progression (delta erosion Sharp score > 1 point) was lower in HCMV+ patients (16.1% versus 25.2%, p = 0.0128) in comparison with HCMV-. HCMV+ status remained independently associated with lower bone erosion progression in multivariate analysis. CONCLUSIONS Our findings suggest that, independently of other confounding factors, HCMV seropositivity is associated with a lower progression of bone erosion during RA.

中文翻译：

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巨细胞病毒血清阳性类风湿关节炎患者的骨质侵蚀进展减少。

背景技术人类巨细胞病毒（HCMV）的血清阳性已经与类风湿关节炎（RA）期间较高的炎症相关。但是，尚无关于HCMV血清反应阳性对RA期间骨侵蚀进展的影响的数据。方法我们选择了487位符合2010 ACR / EULAR RA标准的ESPOIR人群。使用Architect CMV IgG分析法确定了这些患者的HCMV血清学。使用改良的总锋利度分数（mTSS），侵蚀锋利度分数和关节间隙变窄的锋利度分数进行基线和1年中心X线阅读，以量化结构性损伤的进展。我们进行了单变量和多变量分析，以调查HCMV状态与骨侵蚀进展之间的关系。结果我们分析了273例HCMV血清阳性（HCMV +）和214例HCMV血清阴性（HCMV-）RA患者。与HCMV-相比，HCMV +患者接受ACPA +的频率较低（49.8％对58.9％，p <0.0465），而DAS28-ESR较高（5.55±1.24对5.20±1.14，p <0.0013）。与HCMV-相比，HCMV +患者在1年时的骨侵蚀进展（δ侵蚀Sharp评分> 1分）较低（16.1％比25.2％，p = 0.0128）。在多变量分析中，HCMV +状态仍然与较低的骨侵蚀进展独立相关。结论我们的研究结果表明，与其他混杂因素无关，HCMV血清阳性与RA期间骨侵蚀进展的降低相关。与HCMV-相比，HCMV +患者的骨侵蚀进展（δ侵蚀Sharp评分> 1分）更低（16.1％对25.2％，p = 0.0128）。在多变量分析中，HCMV +状态仍然与较低的骨侵蚀进展独立相关。结论我们的研究结果表明，与其他混杂因素无关，HCMV血清阳性与RA期间骨侵蚀进展的降低相关。与HCMV-相比，HCMV +患者的骨侵蚀进展（δ侵蚀Sharp评分> 1分）更低（16.1％对25.2％，p = 0.0128）。在多变量分析中，HCMV +状态仍然与较低的骨侵蚀进展独立相关。结论我们的研究结果表明，与其他混杂因素无关，HCMV血清阳性与RA期间骨侵蚀进展的降低相关。