BACKGROUND Imported loiasis is a rare cause of consultation at the return of stay in central Africa, which often poses difficult diagnostic and therapeutic questions to practitioners especially those who are unaccustomed to tropical medicine. These difficulties can lead to risks for the patients especially if inappropriate treatment is given. Large series of imported loiasis are scarce. METHODS We retrospectively studied the data including outcome in patients diagnosed with imported loiasis between 1993 and 2013 in the Paris area on the basis of a parasitological diagnosis (microfilaremia > 1/ml and/or serologic tests). We compared sub-Saharan and non sub-Saharan African patients. RESULTS Of the 177 identified cases, 167 could be analysed. Sex ratio was 1, mean age 41 years and 83% were sub-Saharan Africans. Cameroon was the main country of exposure (62%). Incubation time may be long (up to 18 months). Of the 167 cases, 57% presented with characteristic symptoms (Calabar swellings, creeping dermatitis, eyeworm) whereas 43% were diagnosed fortuitously. Microfilaremia was evidenced in 105 patients (63%), and specific antibodies in 53%. Compared to sub-Saharan Africans, other patients were presenting less frequently with eyeworm migration and microfilaremia whereas they had higher eosinophilia and positive serology. Prevalence of Calabar swellings was not significantly different between the two groups. Cure rates were 52% with ivermectin alone, and 77% with ivermectin followed by diethylcarbamazine. No severe adverse event was reported. CONCLUSIONS Presentation of imported loiasis varies according to ethnicity. A systematic screening should be recommended in patients with potential exposure in endemic country. Treatment with ivermectin followed by diethylcarbamazine could be a valuable option.

中文翻译：

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法国的进口性精神病：167例病例的回顾性分析，比较了撒哈拉以南非洲地区和非撒哈拉以南非洲地区的患者。

背景技术输入中的狂热症是中非返回时进行咨询的罕见原因，这常常给从业者特别是对热带医学不熟悉的从业者提出困难的诊断和治疗问题。这些困难可能会给患者带来风险，特别是如果给予不适当的治疗。大量的进口性精神病是稀缺的。方法我们根据寄生虫学诊断（微丝虫病> 1 / ml和/或血清学检查），回顾性研究了包括1993年至2013年在巴黎地区诊断为患有进口性精神病的患者的结局数据。我们比较了撒哈拉以南非洲地区和非撒哈拉以南非洲地区的患者。结果在177例确诊病例中，有167例可以进行分析。性别比为1，平均年龄41岁，其中83％为撒哈拉以南非洲人。喀麦隆是暴露的主要国家（62％）。孵育时间可能很长（最多18个月）。在这167例病例中，有57％表现出特征性症状（卡拉巴肿胀，蠕动性皮炎，worm虫），而偶然诊断出43％。105名患者（63％）表现出微丝血症，53％表现出特异性抗体。与撒哈拉以南非洲人相比，其他患者出现eye虫迁移和微丝虫病的频率降低，而他们的嗜酸性粒细胞增多和血清学阳性。两组之间的卡拉巴肿胀患病率无显着差异。单独使用伊维菌素的治愈率为52％，使用伊维菌素和二乙基卡巴嗪的治愈率为77％。没有严重不良反应的报道。结论外来性腰椎病的表现因种族而异。在流行国家有潜在暴露的患者中，应该建议进行系统的筛查。伊维菌素联合二乙基卡巴马嗪治疗可能是一个有价值的选择。