Correlation between blood flow on optic nerve head and structural and functional changes in eyes with glaucoma.,Scientific Reports

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Correlation between blood flow on optic nerve head and structural and functional changes in eyes with glaucoma.
Scientific Reports ( IF 3.8 ) Pub Date : 2020-01-20 , DOI: 10.1038/s41598-020-57583-w
Fumi Kuroda ₁ , Takeshi Iwase ₁ , Kentaro Yamamoto ₁ , Eimei Ra ₁ , Hiroko Terasaki ₁

Affiliation

The purpose of this study was to determine the significance of the correlations between blood flow on the optic nerve head (ONH) using the mean blur rate (MBR) determined by laser speckle flowgraphy and the visual field loss determined by perimetry and the structural alterations by optical coherence tomography in eyes solely with open-angle glaucoma. There were significant differences in the circumpapillary retinal nerve fiber layer thickness (cpRNFLT), and the MBR-tissue, at the different stages of glaucoma (ANOVA, P < 0.001). Univariate linear regression analyses indicated that the mean deviations (MD) were significantly correlated with both the MBR-tissue (r = 0.661, P < 0.001) and the cpRNFLT (r = 0.279, P = 0.005). Logistic regression analyses showed that the MD was significantly correlated with the MBR-tissue (P < 0.001) and the cpRNFLT (P < 0.001). The MBR-tissue was found to be the factor that can best predict the MD based on the Akaike information criteria (P < 0.001). Stepwise multiple logistic regression analyses showed that the MBR-tissue and the cpRNFLT were both risk factors that were significantly associated with the MD (Odds ratio;1.25 and 1.07, P < 0.001 and P < 0.001, respectively). These results indicate that the MBR-tissue was as important as the structural values in diagnosing and determining the prognosis of glaucoma.

中文翻译：

青光眼在视神经头上的血流与眼睛结构和功能变化之间的关系。

这项研究的目的是使用激光散斑成像法确定的平均模糊率（MBR）和视野检查法确定的视野丧失以及通过扫描电镜确定的结构改变来确定视神经乳头（ONH）上的血流之间的相关性。单眼开角型青光眼的光学相干断层扫描在青光眼的不同阶段，环乳头视网膜神经纤维层厚度（cpRNFLT）和MBR组织存在显着差异（ANOVA，P <0.001）。单变量线性回归分析表明，平均偏差（MD）与MBR组织（r = 0.661，P <0.001）和cpRNFLT（r = 0.279，P = 0.005）均显着相关。Logistic回归分析显示MD与MBR组织显着相关（P <0。001）和cpRNFLT（P <0.001）。根据Akaike信息标准，发现MBR组织是最能预测MD的因素（P <0.001）。逐步多元逻辑回归分析显示，MBR组织和cpRNFLT都是与MD显着相关的危险因素（几率分别为1.25和1.07，P <0.001和P <0.001）。这些结果表明，在诊断和确定青光眼的预后中，MBR组织与结构值同样重要。分别为1.25和1.07，P <0.001和P <0.001）。这些结果表明，在诊断和确定青光眼的预后中，MBR组织与结构值同样重要。分别为1.25和1.07，P <0.001和P <0.001）。这些结果表明，在诊断和确定青光眼的预后中，MBR组织与结构值同样重要。

更新日期：2020-01-21

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