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Young cancer survivors have lower bone mineral density compared with healthy controls: a nationwide population-based study in Korea.
Scientific Reports ( IF 3.8 ) Pub Date : 2020-01-20 , DOI: 10.1038/s41598-020-57503-y
Hyoeun Kim 1 , Sunmi Yoo 1 , Seung Guk Park 1
Affiliation  

Direct effects of cancer cells and various cancer treatments can cause bone loss in cancer survivors. The aim of this study was to assess the risk of bone loss in Korean cancer survivors, and the relationship between body composition and bone mineral density (BMD). We hypothesized that cancer survivors would have lower BMD than healthy people, and increased muscle mass has a protective effect on BMD. We measured BMD and body composition in 259 cancer survivors (99 men and 160 women). Subjects were selected from the Korean National Health and Nutrition Survey conducted from 2008 to 2011. Body composition and BMD were measured by dual-energy X-ray absorptiometry. We examined the linear trend of lumbar BMD according to tertiles of lean mass (LM) and fat mass (FM) by linear regression, adjusting for age, alcohol consumption, smoking, exercise, 25-hydroxyvitamin D, height, protein intake, and menopausal status. Cancer survivors under 50 years of age had lower lumbar BMD compared with healthy controls (0.93 ± 0.04 g/cm2 vs. 1.02 ± 0.01 g/cm2, p = 0.032 in males; 0.95 ± 0.02 g/cm2 vs. 0.98 ± 0.01 g/cm2, p = 0.015 in females). Lumbar BMD significantly increased from the lowest to highest tertiles of LM in male (p for trend < 0.001) and marginally significantly increased in female survivors (p for trend = 0.060). In this study of Korean cancer survivors, young survivors were at higher risk of having low lumbar BMD. Higher LM had beneficial effects on BMD in cancer survivors. To prevent osteoporosis and fractures, efforts to increase lean body mass, including bone, are needed for young cancer survivors.

中文翻译:

与健康对照组相比,年轻的癌症幸存者的骨矿物质密度更低:韩国一项基于人群的全国性研究。

癌细胞的直接作用和各种癌症治疗方法可能导致癌症幸存者骨丢失。这项研究的目的是评估韩国癌症幸存者骨丢失的风险,以及身体成分与骨矿物质密度(BMD)之间的关系。我们假设癌症幸存者的BMD低于健康人,而增加的肌肉质量对BMD具有保护作用。我们测量了259名癌症幸存者(99名男性和160名女性)的BMD和身体成分。受试者选自2008年至2011年进行的“韩国国家健康与营养调查”。身体成分和BMD通过双能X射线吸收法测量。我们通过线性回归分析了瘦肉量(LM)和脂肪量(FM)的三分位数,并根据年龄,饮酒量,吸烟,运动,25-羟基维生素D,身高,蛋白质摄入量和更年期状态。与健康对照组相比,50岁以下的癌症幸存者的腰椎BMD较低(男性为0.93±0.04 g / cm2对1.02±0.01 g / cm2,p = 0.032; 0.95±0.02 g / cm2对0.98±0.01 g / cm2,女性中p = 0.015)。男性腰椎骨密度从最低和最高三分位数显着增加(趋势<0.001,p),女性幸存者则显着升高(趋势p = 0.060)。在这项针对韩国癌症幸存者的研究中,年轻的幸存者患低腰椎骨密度的风险更高。较高的LM对癌症幸存者的BMD具有有益作用。为了预防骨质疏松症和骨折,年轻的癌症幸存者需要努力增加包括骨骼在内的瘦体重。与健康对照组相比,50岁以下的癌症幸存者的腰椎BMD较低(男性为0.93±0.04 g / cm2对1.02±0.01 g / cm2,p = 0.032; 0.95±0.02 g / cm2对0.98±0.01 g / cm2,女性中p = 0.015)。男性腰椎骨密度从最低和最高三分位数显着增加(趋势<0.001,p),女性幸存者则显着升高(趋势p = 0.060)。在这项针对韩国癌症幸存者的研究中,年轻的幸存者患低腰椎骨密度的风险更高。较高的LM对癌症幸存者的BMD具有有益作用。为了预防骨质疏松症和骨折,年轻的癌症幸存者需要努力增加包括骨骼在内的瘦体重。与健康对照组相比,50岁以下的癌症幸存者的腰椎BMD较低(男性为0.93±0.04 g / cm2对1.02±0.01 g / cm2,p = 0.032; 0.95±0.02 g / cm2对0.98±0.01 g / cm2,女性中p = 0.015)。男性腰椎骨密度从最低和最高三分位数显着增加(趋势<0.001,p),女性幸存者则显着升高(趋势p = 0.060)。在这项针对韩国癌症幸存者的研究中,年轻的幸存者患低腰椎骨密度的风险更高。较高的LM对癌症幸存者的BMD具有有益作用。为了预防骨质疏松症和骨折,年轻的癌症幸存者需要努力增加包括骨骼在内的瘦体重。01 g / cm2,女性中p = 0.015)。男性腰椎骨密度从最低和最高三分位数显着增加(趋势<0.001,p),女性幸存者则显着升高(趋势p = 0.060)。在这项针对韩国癌症幸存者的研究中,年轻的幸存者患低腰椎骨密度的风险更高。较高的LM对癌症幸存者的BMD具有有益作用。为了预防骨质疏松症和骨折,年轻的癌症幸存者需要努力增加包括骨骼在内的瘦体重。01 g / cm2,女性中p = 0.015)。男性腰椎骨密度从最低和最高三分位数显着增加(趋势<0.001,p),女性幸存者则显着升高(趋势p = 0.060)。在这项针对韩国癌症幸存者的研究中,年轻的幸存者患低腰椎骨密度的风险更高。较高的LM对癌症幸存者的BMD具有有益作用。为了预防骨质疏松症和骨折,年轻的癌症幸存者需要努力增加包括骨骼在内的瘦体重。较高的LM对癌症幸存者的BMD具有有益作用。为了预防骨质疏松症和骨折,年轻的癌症幸存者需要努力增加包括骨骼在内的瘦体重。较高的LM对癌症幸存者的BMD具有有益作用。为了预防骨质疏松症和骨折,年轻的癌症幸存者需要努力增加包括骨骼在内的瘦体重。
更新日期:2020-01-21
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