To further improve the surface properties of polyetheretherketone (PEEK)/nanoporous magnesium calcium silicate (nMCS) composite (PMC), hierarchically porous surface of PMC (PMCF) were created by femtosecond laser, and resveratrol (RV) was incorporated into the porous surface of PMCF ([email protected]). Compared to PMC with flat surface, PMCF contained not only two types of micropores with different sizes (around 20 μm and 0.5 μm) but also nanopores (around 4 nm), which exhibited remarkably increase in surface roughness and protein adsorption. In addition, PMCF displayed a slow-release of RV while PMC showed a burst-release of RV into cell cultured medium. Moreover, compared with PMC and PMCF, [email protected] with antibacterial performances inhibited the growth of E. coli and S. aureus thanks to the release of RV. In addition, compared with PMC, PMCF and [email protected] significantly promoted adhesion and proliferation of rat bone mesenchymal stem cells (BMSC). Furthermore, compared with PMCF, [email protected] obviously enhanced the proliferation and osteogenic differentiation as well as bone related genes expressions of BMSC. The results demonstrated that PMCF with hierarchically porous surface and incorporating of RV displayed antibacterial performances and osteogenic activity in vitro, Therefore, as a drug-loaded implant, [email protected] with good cytocompatibility would have a big potential for applications in orthopaedic fields.

为了进一步改善聚醚醚酮（PEEK）/纳米多孔硅酸钙镁（nMCS）复合材料（PMC）的表面性能，通过飞秒激光创建了PMC（PMCF）的多层多孔表面，并将白藜芦醇（RV）掺入了PMCF（[受电子邮件保护]）。与具有平坦表面的PMC相比，PMCF不仅包含两种不同大小的微孔（约20μm和0.5μm），而且还包含纳米孔（约4 nm），这些微孔的表面粗糙度和蛋白质吸附显着增加。此外，PMCF显示RV缓慢释放，而PMC显示RV突然释放到细胞培养基中。而且，与PMC和PMCF相比，具有抗菌性能的[电子邮件保护]抑制了大肠杆菌和金黄色葡萄球菌的生长。多亏了RV的发布。此外，与PMC相比，PMCF和[电子邮件保护]显着促进大鼠骨间充质干细胞（BMSC）的粘附和增殖。此外，与PMCF相比，[电子邮件保护]明显增强了BMSC的增殖和成骨分化以及骨相关基因的表达。结果表明，具有分级多孔表面并结合RV的PMCF在体外显示出抗菌性能和成骨活性，因此，作为一种载药性良好的植入物，具有良好细胞相容性的[电子邮件保护]在整形外科领域具有广阔的应用潜力。