Obesity and type 2 diabetes have become serious health problems in 21st century. Development of non-invasive treatment to treat obesity and type-2 diabetes is still unmet needs. For targeting on this, one of the promising treatments is to implant an intestine sleeve in the gastrointestinal tract for limitation of food absorption. In this context, biodegradable polymer intestine sleeve was composed of polycaprolactone (PCL), poly-DL-lactic acid (PDLLA) and disk-shape nano-clay (Laponite®), and fabricated as an implantable device. Here, Laponite® as a rheological additive to improve the compatibility of PCL and PDLLA, and the polymers/clay composites were also evaluated by scanning electron microscopy SEM analysis and mechanical measurements. The mass ratio 90/10/1 of PCL/PDLLA/Laponite® composite was selected for fabrication of intestine sleeve, because of the highest toughness and flexibility, which are tensile strength of 91.9 N/mm² and tensile strain of 448% at the failure point. The prepared intestine sleeve was implanted and deployed at the duodenum in type2 diabetic rats, providing significant benefits in control of the body weight and blood glucose, while compared with the non-implanted type 2 diabetic rats. More importantly, the food intake records and histopathological section reports presented that the implanted rats still have normal appetites and no noticeable acute symptoms of inflammation in the end of the test. These appreciable performances suggested the implantation of biocompatible polymer composites has a highly potential treatment for obesity and type 2 diabetes.

肥胖和2型糖尿病已成为21世纪的严重健康问题。仍未满足开发治疗肥胖和2型糖尿病的非侵入性治疗的需求。为此，一种有希望的治疗方法是在胃肠道中植入肠套以限制食物吸收。在这种情况下，可生物降解的聚合物肠套由聚己内酯（PCL），聚DL-乳酸（PDLLA）和盘状纳米粘土（Laponite®）组成，并制成可植入装置。在这里，Laponite®作为流变添加剂以改善PCL和PDLLA的相容性，并且还通过扫描电子显微镜SEM分析和机械测量来评估聚合物/粘土复合材料。选择PCL / PDLLA /Laponite®复合材料的质量比90/10/1，以制造肠套，²，在破坏点的拉伸应变为448％。与未植入2型糖尿病大鼠相比，将准备好的肠套植入并部署在2型糖尿病大鼠的十二指肠，在控制体重和血糖方面具有显着优势。更重要的是，食物摄入记录和组织病理学报告显示，植入的大鼠食欲正常，在试验结束时没有明显的急性炎症症状。这些明显的性能表明，植入生物相容性聚合物复合材料对肥胖症和2型糖尿病具有高度潜在的治疗作用。