Abstract Laser-induced breakdown spectroscopy (LIBS) hyperspectral imaging allows for the determination of two-dimensional and three-dimensional spatial distributions of elemental species throughout complex samples. In this work, LIBS hyperspectral imaging was utilized to investigate minor elemental species within tablets. Representative LIBS spectra were initially collected on four complex, heterogeneous tablets, showing high concentrations of Ti in the tablet coating, with low and variable abundance of Na, Mg, and K. Principal component analysis revealed distinct resolution of the four tablets due to differences in Na, Mg, and K. Using two-dimensional LIBS hyperspectral imaging, spatial distributions of Na, Mg, and K within defined x and y regions of the tablet coating were generated. Subsequent three-dimensional LIBS hyperspectral imaging further elucidated the full x, y, and z spatial distributions of these minor elemental species within the tablet surface, tablet coating, and tablet core. As such, in situ depth profiling of the minor elemental species within each tablet was accomplished. Quantification of the homogeneity and uniformity of each tablet was determined. To our knowledge, this is the first report of multivariate analysis, LIBS, and LIBS hyperspectral imaging being utilized for the determination of both 2D and 3D spatial distributions of minor elemental species, along with quantification of tablet homogeneity, within tablets.

中文翻译：

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通过激光诱导击穿光谱高光谱成像使用原位深度分析研究片剂中的微量元素种类

摘要 激光诱导击穿光谱 (LIBS) 高光谱成像允许确定整个复杂样品中元素种类的二维和三维空间分布。在这项工作中，LIBS 高光谱成像用于研究片剂中的微量元素种类。代表性的 LIBS 光谱最初是在四种复杂的异质片剂上收集的，显示片剂包衣中的 Ti 浓度很高，Na、Mg 和 K 的丰度低且可变。 主成分分析显示，由于在Na、Mg 和 K。使用二维 LIBS 高光谱成像，生成了 Na、Mg 和 K 在片剂包衣的定义 x 和 y 区域内的空间分布。随后的三维 LIBS 高光谱成像进一步阐明了这些微量元素在片剂表面、片剂包衣和片芯中的完整 x、y 和 z 空间分布。因此，完成了对每个片剂内次要元素种类的原位深度分析。确定每个片剂的同质性和均一性的量化。据我们所知，这是多变量分析、LIBS 和 LIBS 高光谱成像的第一份报告，用于确定微量元素种类的 2D 和 3D 空间分布，以及片剂内片剂均匀性的量化。完成了每片内微量元素种类的原位深度分析。确定每个片剂的同质性和均一性的量化。据我们所知，这是多变量分析、LIBS 和 LIBS 高光谱成像的第一份报告，用于确定微量元素种类的 2D 和 3D 空间分布，以及片剂内片剂均匀性的量化。完成了每片内微量元素种类的原位深度分析。确定每个片剂的同质性和均一性的量化。据我们所知，这是多变量分析、LIBS 和 LIBS 高光谱成像的第一份报告，用于确定微量元素种类的 2D 和 3D 空间分布，以及片剂内片剂均匀性的量化。