Abstract A novel 4-amino-1, 8-naphthalimide-based fluorescent sensor, with mono iminoethoxyacetic acid as receptor, was developed. It was applied successfully to detect Zn2+ in living cells. Under physiological pH conditions, it demonstrates high selectivity and sensitivity for sensing Zn2+ with about 5-fold enhancement in aqueous solution, with a characteristic emission band of 4-amino-1, 8-naphthalimide with a green color centered at 550 nm. DFT calculations shows Zn2+ is coordinated by the N and O atoms of the iminoethoxyacetic acid arms and methoxy group to form the distorted four-coordination geometry.

中文翻译：

---

具有高选择性和灵敏度的基于萘酰亚胺的 Zn2+ 荧光传感器及其在活细胞中的成像

摘要 研制了一种以单亚氨基乙氧基乙酸为受体的新型4-氨基-1, 8-萘二甲酰亚胺基荧光传感器。成功应用于活细胞中Zn2+的检测。在生理 pH 条件下，它表现出对 Zn2+ 的高选择性和灵敏度，在水溶液中增强约 5 倍，具有 4-amino-1, 8-naphthalimide 的特征发射带，绿色中心在 550 nm。DFT 计算表明 Zn2+ 被亚氨基乙氧基乙酸臂的 N 和 O 原子和甲氧基配位，形成扭曲的四配位几何结构。