The innovation of novel and proficient nanostructured materials for the precise level determination of pharmaceuticals in biological fluids is quite crucial to the researchers. With this in mind, we synthesized iron molybdate nanoplates (Fe2(MoO4)3; FeMo NPs) via simple ultrasonic-assisted technique (70 kHz with a power of 100 W). The FeMo NPs were used as the efficient electrocatalyst for electrochemical oxidation of first-generation antihistamine drug- Promethazine hydrochloride (PMH). The as-synthesized FeMo NPs were characterized and confirmed by various characterization techniques such as XRD, Raman, FT-IR, FE-SEM, EDX and Elemental mapping analysis and electron impedance spectroscopy (EIS). In addition, the electrochemical characteristic features of FeMo NPs were scrutinized by electrochemical techniques like cyclic voltammetry (CV) and differential pulse voltammetry technique (DPV). Interestingly, the developed FeMo NPs modified glassy carbon electrode (FeMo NPs/GCE) discloses higher peak current with lesser anodic potential on comparing to bare GCE including wider linear range (0.01-68.65 µM), lower detection limit (0.01 µM) and greater sensitivity (0.97 µAµM-1cm-2). Moreover, the as-synthesized FeMo NPs applied for selectivity, reproducibility, repeatability and storage ability to investigate the practical viability. In the presence of interfering species like cationic, anionic and biological samples, the oxidation peak current response doesn't cause any variation results disclose good selectivity towards the detection of PMH. Additionally, the practical feasibility of the FeMo NPs/GCE was tested by real samples like, commercial tablet (Phenergan 25 mg Tablets) and lake water samples which give satisfactory recovery results. All the above consequences made clear that the proposed sensor FeMo NPs/GCE exhibits excellent electrochemical behavior for electrochemical determination towards oxidation of antihistamine drug PMH.

中文翻译：

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超声辅助合成的纳米板状钼酸铁：在玻碳电极上制备，作为修饰电极，用于选择性测定第一代抗组胺药盐酸异丙嗪。

对于研究人员而言，创新和精通纳米结构材料以精确测定生物流体中药物含量的创新是至关重要的。考虑到这一点，我们通过简单的超声辅助技术（70 kHz，功率为100 W）合成了钼酸铁纳米板（Fe2（MoO4）3; FeMo NPs）。FeMo NPs被用作第一代抗组胺药盐酸异丙嗪（PMH）电化学氧化的有效电催化剂。通过各种表征技术，如XRD，拉曼，FT-IR，FE-SEM，EDX以及元素映射分析和电子阻抗谱（EIS），对合成后的FeMo NP进行了表征和确认。此外，通过循环伏安法（CV）和差分脉冲伏安法（DPV）等电化学技术对FeMo NPs的电化学特征进行了研究。有趣的是，与裸GCE相比，已开发的FeMo NPs修饰玻碳电极（FeMo NPs / GCE）具有更高的峰值电流和更小的阳极电位，包括更宽的线性范围（0.01-68.65 µM），更低的检测极限（0.01 µM）和更高的灵敏度。 （0.97 µAµM-1cm-2）。此外，合成后的FeMo NPs用于选择性，可重复性，可重复性和储存能力，以研究实际的可行性。在存在阳离子，阴离子和生物样品等干扰物质的情况下，氧化峰电流响应不会引起任何变化，结果表明对PMH的检测具有良好的选择性。此外，FeMo NPs / GCE的实际可行性已通过实际样品进行了测试，例如市售片剂（Phenergan 25 mg片剂）和湖水样品，其回收率令人满意。以上所有结果清楚表明，拟议的传感器FeMo NPs / GCE表现出优异的电化学行为，可用于电化学测定抗组胺药PMH的氧化。