Metabolic processes occurring during host-microbiota-pathogen interactions can favorably or negatively influence host survival during infection. Defining the metabolic needs of the three players, the mechanisms through which they acquire nutrients, and whether each participant cooperates or competes with each other to meet their own metabolic demands during infection has the potential to reveal new approaches to treat disease. Here, we review topical findings in organismal metabolism and infection and highlight four emerging lines of investigation: how host-microbiota metabolic partnerships protect against infection; competition for glucose between host and pathogen; significance of infection-induced anorexia; and redefinition of the role of iron during infection. We also discuss how these discoveries shape our understanding of infection biology and their likely therapeutic value.

中文翻译：

---

在生物水平上对感染的代谢适应。

在宿主-微生物-病原体相互作用过程中发生的代谢过程可能对感染期间宿主的存活产生有利或负面影响。定义三个参与者的代谢需求，他们获取营养的机制，以及每个参与者在感染期间是否相互合作或竞争以满足自己的代谢需求，都有可能揭示治疗疾病的新方法。在这里，我们回顾了有关有机物代谢和感染的主题研究结果，并突出了四个新兴的研究方向：宿主-微生物群落代谢伙伴关系如何预防感染；宿主与病原体之间的葡萄糖竞争；感染引起的厌食的意义；并重新定义铁在感染过程中的作用。