Approximately 10% of dementia patients have idiopathic normal pressure hydrocephalus (iNPH), an expansion of the cerebrospinal fluid (CSF)-filled brain ventricles. iNPH and Alzheimer's disease (AD) both exhibit sleep disturbances, build-up of brain metabolic wastes and amyloid-β (Aβ) plaques, perivascular reactive astrogliosis, and mislocalization of astrocyte aquaporin-4 (AQP4). The glia-lymphatic (glymphatic) system facilitates brain fluid clearance and waste removal during sleep via glia-supported perivascular channels. Human studies have implicated impaired glymphatic function in both AD and iNPH. Continued investigation into the role of glymphatic system biology in AD and iNPH models could lead to new strategies to improve brain health by restoring homeostatic brain metabolism and CSF dynamics.

中文翻译：

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阿尔茨海默病和特发性正常压力脑积水的 Glymphatic System 受损。

大约 10% 的痴呆症患者患有特发性正常压力脑积水 (iNPH)，这是一种充满脑脊液 (CSF) 的脑室的扩张。iNPH 和阿尔茨海默病 (AD) 都表现出睡眠障碍、脑代谢废物和淀粉样蛋白 β (Aβ) 斑块的积聚、血管周围反应性星形胶质细胞增生和星形胶质细胞水通道蛋白 4 (AQP4) 的错误定位。胶质淋巴（glymphatic）系统通过胶质支持的血管周围通道促进睡眠期间的脑液清除和废物清除。人类研究表明 AD 和 iNPH 中的淋巴功能受损。继续研究类淋巴系统生物学在 AD 和 iNPH 模型中的作用可能会导致通过恢复稳态脑代谢和脑脊液动力学来改善大脑健康的新策略。