N6-Methyladenosine (m6A), the most prevalent internal modification associated with eukaryotic mRNAs, influences many steps of mRNA metabolism, including splicing, export, and translation, as well as stability. Recent studies have revealed that m6A-containing mRNAs undergo one of two distinct pathways of rapid degradation: deadenylation via the YT521-B homology (YTH) domain-containing family protein 2 (YTHDF2; an m6A reader protein)-CCR4/NOT (deadenylase) complex or endoribonucleolytic cleavage by the YTHDF2-HRSP12-ribonuclease (RNase) P/mitochondrial RNA-processing (MRP) (endoribonuclease) complex. Some m6A-containing circular RNAs (circRNAs) are also subject to endoribonucleolytic cleavage by YTHDF2-HRSP12-RNase P/MRP. Here, we highlight recent progress on the molecular mechanisms underlying rapid mRNA degradation via m6A and describe our current understanding of the dynamic regulation of m6A-mediated mRNA decay through the crosstalk between m6A (or YTHDF2) and other cellular factors.

中文翻译：

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通过 m6A 修饰驱动 mRNA 降解的分子机制。

N6-甲基腺苷 (m6A) 是与真核 mRNA 相关的最普遍的内部修饰，影响 mRNA 代谢的许多步骤，包括剪接、输出和翻译，以及稳定性。最近的研究表明，含有 m6A 的 mRNA 经历了两种不同的快速降解途径之一：通过含有 YT521-B 同源 (YTH) 结构域的家族蛋白 2（YTHDF2；一种 m6A 阅读器蛋白）-CCR4/NOT（去腺苷酸酶）进行去腺苷酸化YTHDF2-HRSP12-核糖核酸酶 (RNase) P/线粒体 RNA 加工 (MRP)（内切核糖核酸酶）复合物的复合物或内切核糖核酸裂解。一些含有 m6A 的环状 RNA (circRNAs) 也受到 YTHDF2-HRSP12-RNase P/MRP 的内切核糖核酸切割。这里，