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Celastrol: Progresses in structure-modifications, structure-activity relationships, pharmacology and toxicology.
European Journal of Medicinal Chemistry ( IF 6.0 ) Pub Date : 2020-01-20 , DOI: 10.1016/j.ejmech.2020.112081
Wei Hou 1 , Bo Liu 2 , Hongtao Xu 3
Affiliation  

Celastrol, a principal bioactive ingredient of Tripterygium wilfordii Hook F, has gained extensive exploration due to its unique structure features and multiple promising biological activities. This review will focus on the structural modifications, structure-activity relationships, pharmacology, and toxicology of celastrol in the past ten years. We hope this review would be helpful to get a better grasp of the progresses in the field and provide constructive suggestions for the further study of celastrol.

中文翻译:

Celastrol:结构修饰,结构-活性关系,药理和毒理学方面的进展。

雷公藤的主要生物活性成分Celastrol因其独特的结构特征和多种有前途的生物活性而得到了广泛的探索。这项审查将侧重于过去十年中Celastrol的结构修饰,构效关系,药理学和毒理学。我们希望这篇综述将有助于更好地掌握该领域的进展,并为进一步研究天青素提供建设性的建议。
更新日期:2020-01-21
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