Amino acid transporters as tetraspanin TM4SF5 binding partners.,Experimental & Molecular Medicine

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Amino acid transporters as tetraspanin TM4SF5 binding partners.
Experimental & Molecular Medicine ( IF 9.5 ) Pub Date : 2020-01-20 , DOI: 10.1038/s12276-019-0363-7
Jae Woo Jung ₁ , Ji Eon Kim ₂ , Eunmi Kim ₂ , Jung Weon Lee _{1,

2}

Affiliation

Transmembrane 4 L6 family member 5 (TM4SF5) is a tetraspanin that has four transmembrane domains and can be N-glycosylated and palmitoylated. These posttranslational modifications of TM4SF5 enable homophilic or heterophilic binding to diverse membrane proteins and receptors, including growth factor receptors, integrins, and tetraspanins. As a member of the tetraspanin family, TM4SF5 promotes protein-protein complexes for the spatiotemporal regulation of the expression, stability, binding, and signaling activity of its binding partners. Chronic diseases such as liver diseases involve bidirectional communication between extracellular and intracellular spaces, resulting in immune-related metabolic effects during the development of pathological phenotypes. It has recently been shown that, during the development of fibrosis and cancer, TM4SF5 forms protein-protein complexes with amino acid transporters, which can lead to the regulation of cystine uptake from the extracellular space to the cytosol and arginine export from the lysosomal lumen to the cytosol. Furthermore, using proteomic analyses, we found that diverse amino acid transporters were precipitated with TM4SF5, although these binding partners need to be confirmed by other approaches and in functionally relevant studies. This review discusses the scope of the pathological relevance of TM4SF5 and its binding to certain amino acid transporters.

中文翻译：

氨基酸转运蛋白作为四跨膜蛋白 TM4SF5 结合伙伴。

Transmembrane 4 L6 家族成员 5 (TM4SF5) 是一种四跨膜蛋白，具有四个跨膜结构域，可以被 N-糖基化和棕榈酰化。TM4SF5 的这些翻译后修饰能够与多种膜蛋白和受体（包括生长因子受体、整合素和四跨膜蛋白）进行同嗜或异嗜结合。作为四跨膜蛋白家族的一员，TM4SF5 促进蛋白质-蛋白质复合物对其结合伙伴的表达、稳定性、结合和信号活性进行时空调节。肝病等慢性疾病涉及细胞外和细胞内空间之间的双向通讯，导致病理表型发展过程中的免疫相关代谢效应。最近表明，在纤维化和癌症的发展过程中，TM4SF5 与氨基酸转运蛋白形成蛋白质-蛋白质复合物，可调节胱氨酸从细胞外空间摄取至胞质溶胶以及精氨酸从溶酶体腔输出至胞质溶胶。此外，使用蛋白质组学分析，我们发现不同的氨基酸转运蛋白与 TM4SF5 沉淀，尽管这些结合伙伴需要通过其他方法和功能相关研究来确认。本综述讨论了 TM4SF5 的病理相关性范围及其与某些氨基酸转运蛋白的结合。我们发现 TM4SF5 沉淀了多种氨基酸转运蛋白，尽管这些结合伙伴需要通过其他方法和功能相关研究来确认。本综述讨论了 TM4SF5 的病理相关性范围及其与某些氨基酸转运蛋白的结合。我们发现 TM4SF5 沉淀了多种氨基酸转运蛋白，尽管这些结合伙伴需要通过其他方法和功能相关研究来确认。本综述讨论了 TM4SF5 的病理相关性范围及其与某些氨基酸转运蛋白的结合。

更新日期：2020-01-21

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