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A novel versatile yolk-shell nanosystem based on NIR-elevated drug release and GSH depletion-enhanced Fenton-like reaction for synergistic cancer therapy.
Colloids and Surfaces B: Biointerfaces ( IF 5.4 ) Pub Date : 2020-01-20 , DOI: 10.1016/j.colsurfb.2020.110810 Dihai Gu 1 , Peijing An 1 , Xiuli He 1 , Hongshuai Wu 1 , Zhiguo Gao 1 , Yaojia Li 1 , Fanghui Chen 1 , Kaiwu Cheng 1 , Yuchen Zhang 1 , Chaoqun You 1 , Baiwang Sun 1
Colloids and Surfaces B: Biointerfaces ( IF 5.4 ) Pub Date : 2020-01-20 , DOI: 10.1016/j.colsurfb.2020.110810 Dihai Gu 1 , Peijing An 1 , Xiuli He 1 , Hongshuai Wu 1 , Zhiguo Gao 1 , Yaojia Li 1 , Fanghui Chen 1 , Kaiwu Cheng 1 , Yuchen Zhang 1 , Chaoqun You 1 , Baiwang Sun 1
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In this study, a versatile doxorubicin (DOX)-loaded yolk-shell nano-particles (HMCMD) assembled with manganese dioxide (MnO2) as the core and copper sulfide (HMCuS) as the mesoporous (∼ 6.4 nm) shell, was designed and synthesized. The resulting HMCMD possess excellent photothermal conversion efficiency. The DOX release from the yolk-shell nanoparticles could be promoted by laser irradiation, which increased the chemotherapy of DOX. Meanwhile, Mn2+ could be released from the HMCMD through a redox reaction between MnO2 and abundant glutathione (GSH) in tumor cells. The released Mn2+ could promote the decomposition of the intracellular hydrogen peroxide (H2O2) by Fenton-like reaction to generate the highly toxic hydroxyl radicals (·OH), thus exhibiting the effective chemodynamic therapy (CDT). Additionally, the efficiency of Mn2+-mediated CDT could be effectively enhanced by NIR irradiation. Further modification of polyethylene glycol (PEG) would improve the water solubility of the HMCMD to promote the uptake by MCF-7 cells. Hence, the HMCMD with synergistic effects of chemotherapy and chemodynamic/photothermal therapy would provide an alternative strategy in antitumor research.
中文翻译：
一种基于NIR增强药物释放和GSH耗竭增强Fenton样反应的新型多功能卵黄壳纳米系统，用于协同癌症治疗。
在这项研究中，设计并负载了一种由多柔比星（DOX）负载的卵黄壳纳米颗粒（HMCMD），其组装为以二氧化锰（MnO2）为核，硫化铜（HMCuS）作为中孔（〜6.4 nm）壳。合成的。所得的HMMCD具有优异的光热转化效率。激光辐照可促进蛋黄壳纳米颗粒中DOX的释放，从而增加DOX的化学疗法。同时，Mn2 +可以通过MnO2与肿瘤细胞中丰富的谷胱甘肽（GSH）之间的氧化还原反应从HMCMD中释放出来。释放的Mn2 +可以通过Fenton样反应促进细胞内过氧化氢（H2O2）分解，产生高毒性的羟基自由基（·OH），从而表现出有效的化学动力学疗法（CDT）。另外，NIR辐照可以有效提高Mn2 +介导的CDT的效率。聚乙二醇（PEG）的进一步修饰将改善HMCMD的水溶性，从而促进MCF-7细胞的摄取。因此，具有化学疗法和化学动力学/光热疗法的协同作用的HMCMD将为抗肿瘤研究提供替代策略。
更新日期：2020-01-21
中文翻译：
一种基于NIR增强药物释放和GSH耗竭增强Fenton样反应的新型多功能卵黄壳纳米系统，用于协同癌症治疗。
在这项研究中，设计并负载了一种由多柔比星（DOX）负载的卵黄壳纳米颗粒（HMCMD），其组装为以二氧化锰（MnO2）为核，硫化铜（HMCuS）作为中孔（〜6.4 nm）壳。合成的。所得的HMMCD具有优异的光热转化效率。激光辐照可促进蛋黄壳纳米颗粒中DOX的释放，从而增加DOX的化学疗法。同时，Mn2 +可以通过MnO2与肿瘤细胞中丰富的谷胱甘肽（GSH）之间的氧化还原反应从HMCMD中释放出来。释放的Mn2 +可以通过Fenton样反应促进细胞内过氧化氢（H2O2）分解，产生高毒性的羟基自由基（·OH），从而表现出有效的化学动力学疗法（CDT）。另外，NIR辐照可以有效提高Mn2 +介导的CDT的效率。聚乙二醇（PEG）的进一步修饰将改善HMCMD的水溶性，从而促进MCF-7细胞的摄取。因此，具有化学疗法和化学动力学/光热疗法的协同作用的HMCMD将为抗肿瘤研究提供替代策略。
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