当前位置：
X-MOL 学术
›
Colloids Surf. B Biointerfaces
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Lycopene used as Anti-inflammatory Nanodrug for the Treatment of Rheumathoid Arthritis: Animal assay, Pharmacokinetics, ABC Transporter and Tissue Deposition.
Colloids and Surfaces B: Biointerfaces ( IF 5.4 ) Pub Date : 2020-01-20 , DOI: 10.1016/j.colsurfb.2020.110814 Vivian Meira Moia 1 , Filipe Leal Portilho 1 , Tatiana Almeida Pádua 2 , Luana Barbosa Corrêa 2 , Eduardo Ricci-Junior 3 , Elaine Cruz Rosas 2 , Luiciana Magalhaes Rebelo Alencar 4 , Francisco Savio Mendes Sinfronio 5 , Angelina Sampson 6 , Surtaj Hussain Iram 6 , Frank Alexis 7 , Maria dasGraccedilasMuller de OliveiraHenriques 2 , Ralph Santos-Oliveira 8
Colloids and Surfaces B: Biointerfaces ( IF 5.4 ) Pub Date : 2020-01-20 , DOI: 10.1016/j.colsurfb.2020.110814 Vivian Meira Moia 1 , Filipe Leal Portilho 1 , Tatiana Almeida Pádua 2 , Luana Barbosa Corrêa 2 , Eduardo Ricci-Junior 3 , Elaine Cruz Rosas 2 , Luiciana Magalhaes Rebelo Alencar 4 , Francisco Savio Mendes Sinfronio 5 , Angelina Sampson 6 , Surtaj Hussain Iram 6 , Frank Alexis 7 , Maria dasGraccedilasMuller de OliveiraHenriques 2 , Ralph Santos-Oliveira 8
Affiliation
|
Lycopene is a carotenoid drug that has demonstrated several properties, including antioxidant and anti-inflammatory activity. The absorption in human body is very low (10-30 % only). In order to increase the bioavailability, lycopene nanoemulsion was formulated and characterized (atomic force microscopy, thermogravimetric analysis dynamic light scattering and differential scanning calorimetry). Also in vitro assay to evaluate the at-binding with MPR1 was performed. Finally, in vivo assay in animals inducted with rheumathoid arthritis were performed. The results showed that the formulated nanolycopene had superior efficacy when compared with the conventional lycopene (not nano-formulated) in inducted animals (rheumatoid arthritis). The results support the use of nanolycopene as an anti-inflammatory agent for rheumatoid arthritis therapy.
中文翻译：
番茄红素用作治疗类风湿关节炎的抗炎纳米药物：动物分析，药代动力学，ABC转运蛋白和组织沉积。
番茄红素是一种类胡萝卜素药物，具有多种特性，包括抗氧化剂和抗炎活性。人体吸收非常低（仅10％至30％）。为了提高生物利用度，配制并表征了番茄红素纳米乳液（原子力显微镜，热重分析，动态光散射和差示扫描量热法）。还进行了体外测定以评价与MPR1的at-结合。最后，在风湿性关节炎诱发的动物中进行体内测定。结果表明，与常规番茄红素（非纳米配方）相比，配制的纳米番茄红素在诱发动物（类风湿关节炎）中具有更好的疗效。结果支持使用纳米番茄红素作为类风湿关节炎治疗的抗炎药。
更新日期：2020-01-21
中文翻译：
番茄红素用作治疗类风湿关节炎的抗炎纳米药物：动物分析，药代动力学，ABC转运蛋白和组织沉积。
番茄红素是一种类胡萝卜素药物，具有多种特性，包括抗氧化剂和抗炎活性。人体吸收非常低（仅10％至30％）。为了提高生物利用度，配制并表征了番茄红素纳米乳液（原子力显微镜，热重分析，动态光散射和差示扫描量热法）。还进行了体外测定以评价与MPR1的at-结合。最后，在风湿性关节炎诱发的动物中进行体内测定。结果表明，与常规番茄红素（非纳米配方）相比，配制的纳米番茄红素在诱发动物（类风湿关节炎）中具有更好的疗效。结果支持使用纳米番茄红素作为类风湿关节炎治疗的抗炎药。
京公网安备 11010802027423号