The integrity of the cytoskeleton is essential to diverse cellular processes such as phagocytosis and intracellular trafficking. Disruption of the organization and dynamics of the actin cytoskeleton leads to age-associated symptoms and diseases, ranging from cancer to neurodegeneration. In addition, changes in the integrity of the actin cytoskeleton disrupt the functioning of not only somatic and stem cells but also gametes, resulting in aberrant embryonic development. Strategies to preserve the integrity and dynamics of the cytoskeleton are, therefore, potentially therapeutic to age-related disorders. The objective of this article is to revisit the current understanding of the roles played by the actin cytoskeleton in aging, and to review the opportunities and challenges for the transition of basic research into intervention development. It is hoped that, with the snapshot of evidence regarding changes in actin dynamics with advanced age, insights into future research directions can be attained.

细胞骨架的完整性对于多种细胞过程如吞噬作用和细胞内运输至关重要。肌动蛋白细胞骨架的组织和动力学破坏导致与年龄相关的症状和疾病，从癌症到神经退行性变。此外，肌动蛋白细胞骨架完整性的改变不仅破坏了体细胞和干细胞的功能，还破坏了配子的功能，从而导致异常的胚胎发育。因此，保留细胞骨架完整性和动态性的策略可能会治疗与年龄有关的疾病。本文的目的是重新了解肌动蛋白细胞骨架在衰老中的作用的当前理解，并回顾基础研究向干预发展过渡的机遇和挑战。