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CSF SerpinA1 in Creutzfeldt-Jakob disease and frontotemporal lobar degeneration.
Annals of Clinical and Translational Neurology ( IF 4.4 ) Pub Date : 2020-01-20 , DOI: 10.1002/acn3.50980
Samir Abu-Rumeileh 1 , Steffen Halbgebauer 2 , Petra Steinacker 2 , Sarah Anderl-Straub 2 , Barbara Polischi 3 , Albert C Ludolph 2 , Sabina Capellari 1, 3 , Piero Parchi 3, 4 , Markus Otto 2
Affiliation  

SerpinA1 (alpha‐1 antitrypsin) is an acute inflammatory protein, which seems to play a role in neurodegeneration and neuroinflammation. In Alzheimer’s disease and synucleinopathies, SerpinA1 is overexpressed in the brain and the cerebrospinal fluid (CSF) showing abnormal patterns of its charge isoforms. To date, no comprehensive studies explored SerpinA1 CSF isoforms in Creutzfeldt–Jakob disease (CJD) and frontotemporal lobar degeneration (FTLD).

中文翻译:

CSF SerpinA1 在克雅氏病和额颞叶变性中的作用。

SerpinA1(α-1 抗胰蛋白酶)是一种急性炎症蛋白,似乎在神经变性和神经炎症中起作用。在阿尔茨海默病和突触核蛋白病中,SerpinA1 在大脑和脑脊液 (CSF) 中过度表达,显示其电荷异构体的异常模式。迄今为止,尚无综合研究探讨克雅氏病 (CJD) 和额颞叶变性 (FTLD) 中的 SerpinA1 CSF 亚型。
更新日期:2020-01-20
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