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Association of serum vitamin D with frailty in older Korean adults
Maturitas ( IF 3.9 ) Pub Date : 2020-04-01 , DOI: 10.1016/j.maturitas.2020.01.008
Jinhee Kim 1 , Yunhwan Lee 1 , Chang Won Won 2 , Seunghee Kye 3 , Jee-Seon Shim 4
Affiliation  

OBJECTIVES The association between serum levels of vitamin D and frailty in older Korean adults was examined. STUDY DESIGN Cross-sectional study. Older people living in the community across 10 study centers throughout South Korea. The baseline data (2016-2017) of 2872 participants aged 70-84 years in the Korean Frailty and Aging Cohort Study were evaluated. MAIN OUTCOME MEASURES Serum vitamin D level was assessed with an electro-chemiluminescence immunoassay. Frailty was defined using Fried's frailty index. A multinomial logistic regression analysis was used to examine the association between serum levels of vitamin D and frailty. RESULTS The percentages of those with serum vitamin D levels of <25 nmol/L, 25-49 nmol/L, 50-74 nmol/L, and ≥75 nmol/L were 4.1 %, 37.0 %, 37.8 %, and 21.0 %, respectively. The prevalence of frailty was 9.7 %. Those with lower serum vitamin D levels, compared with ≥75 nmol/L, tended to have higher odds of being frail than being non-frail (OR: 1.58, 95 % CI: 1.05-2.39 for 50-74 nmol/L; OR: 1.49, 95 % CI: 0.98-2.26 for 25-49 nmol/L; OR: 1.37, 95 % CI: 0.65-2.88 for <25 nmol/L). Among the components of frailty, low grip strength was significantly associated with lower serum levels of vitamin D. CONCLUSIONS Low serum levels of vitamin D are associated with an increased likelihood of frailty in community-dwelling older adults, suggesting a potentially protective role of vitamin D against frailty.

中文翻译:

血清维生素 D 与韩国老年人虚弱的关系

目的 研究韩国老年人血清维生素 D 水平与虚弱之间的关系。研究设计横断面研究。居住在整个韩国 10 个学习中心的社区中的老年人。评估了韩国虚弱和老龄化队列研究中 2872 名 70-84 岁参与者的基线数据(2016-2017 年)。主要观察指标 血清维生素 D 水平通过电化学发光免疫测定法进行评估。虚弱是使用弗里德的虚弱指数来定义的。多项逻辑回归分析用于检查血清维生素 D 水平与虚弱之间的关联。结果血清维生素D水平<25 nmol/L、25-49 nmol/L、50-74 nmol/L和≥75 nmol/L的比例分别为4.1 %、37.0 %、37.8 %和21.0 % , 分别。虚弱的患病率为 9.7%。与 ≥ 75 nmol/L 相比,血清维生素 D 水平较低的患者体弱比非体弱的几率更高(OR:1.58,95 % CI:50-74 nmol/L 为 1.05-2.39;OR : 1.49, 95 % CI: 0.98-2.26 for 25-49 nmol/L; OR: 1.37, 95% CI: 0.65-2.88 for <25 nmol/L)。在虚弱的组成部分中,低握力与较低的血清维生素 D 水平显着相关。 结论 低血清维生素 D 水平与居住在社区的老年人虚弱的可能性增加有关,表明维生素 D 具有潜在的保护作用反对虚弱。25 毫摩尔/升)。在虚弱的组成部分中,低握力与较低的血清维生素 D 水平显着相关。 结论 低血清维生素 D 水平与居住在社区的老年人虚弱的可能性增加有关,表明维生素 D 具有潜在的保护作用反对虚弱。25 毫摩尔/升)。在虚弱的组成部分中,低握力与较低的血清维生素 D 水平显着相关。 结论 低血清维生素 D 水平与居住在社区的老年人虚弱的可能性增加有关,表明维生素 D 具有潜在的保护作用反对虚弱。
更新日期:2020-04-01
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