Neurotrophin-3-Loaded Multichannel Nanofibrous Scaffolds Promoted Anti-Inflammation, Neuronal Differentiation, and Functional Recovery after Spinal Cord Injury,ACS Biomaterials Science & Engineering

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Neurotrophin-3-Loaded Multichannel Nanofibrous Scaffolds Promoted Anti-Inflammation, Neuronal Differentiation, and Functional Recovery after Spinal Cord Injury
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-01-29 , DOI: 10.1021/acsbiomaterials.0c00023
Xiumin Sun _{1,

2} , Chi Zhang ₁ , Jinghui Xu ₃ , Hong Zhai ₁ , Sheng Liu ₁ , Yiwei Xu ₁ , Yong Hu ₄ , Houqing Long ₃ , Ying Bai ₅ , Daping Quan _{1,

5}

Affiliation

The clinical therapeutics for nerve tissue regeneration and functional recovery after spinal cord injury (SCI) are very limited because of the complex biological processes and inhibitory microenvironment. Advanced biomaterials are highly desired to avoid severe secondary damage and provide guidance for axonal regrowth. Multichannel nanofibrous scaffolds were modified with gelatin and cross-linked by genipin. The gelatin-coated nanofibers exhibited strong binding affinity with neurotrophin-3, which underwent a well-controlled release and highly promoted neuronal differentiation and synapse formation of the seeded neural stem cells. The nanofibrous scaffolds fabricated by combinatorial biomaterials were implanted into complete transected spinal cords in rats. Not only were the inflammatory responses and collagen/astrocytic scar formation limited, but the functional neurons and remyelination were facilitated postsurgery, leading to highly improved functional restoration. This nanofibrous scaffold with high specific surface area can be easily modified with biomolecules, which was proven to be effective for nerve regeneration after transected SCI, and provided a springboard for advanced scaffold design in clinical applications.

中文翻译：

加载 Neurotrophin-3 的多通道纳米纤维支架促进脊髓损伤后的抗炎、神经元分化和功能恢复

由于复杂的生物学过程和抑制性微环境，脊髓损伤（SCI）后神经组织再生和功能恢复的临床治疗非常有限。非常需要先进的生物材料来避免严重的二次损伤并为轴突再生提供指导。多通道纳米纤维支架用明胶修饰并通过京尼平交联。涂有明胶的纳米纤维与神经营养因子 3 表现出很强的结合亲和力，神经营养因子 3 的释放受到良好控制，并高度促进了种子神经干细胞的神经元分化和突触形成。将由组合生物材料制成的纳米纤维支架植入大鼠完全横断的脊髓中。不仅炎症反应和胶原蛋白/星形胶质细胞疤痕的形成受到限制，但功能性神经元和髓鞘再生在术后得到促进，从而大大改善了功能恢复。这种具有高比表面积的纳米纤维支架可以很容易地用生物分子进行修饰，被证明对横断脊髓损伤后的神经再生有效，并为临床应用中先进的支架设计提供了跳板。

更新日期：2020-01-29

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