There is increasing recognition of the role the microbiome plays in states of health and disease. Microbiome studies in systemic autoimmune diseases demonstrate unique microbial patterns in Inflammatory Bowel Disease, Rheumatoid Arthritis, and Systemic Lupus Erythematosus to a lesser extent, whereas there is no single bug or pattern that characterizes Multiple Sclerosis. Autoimmune diseases tend to share a predisposition for vitamin D deficiency, which alters the microbiome and integrity of the gut epithelial barrier. In this review, we summarize the influence of intestinal bacteria on the immune system, explore the microbial patterns that have emerged from studies on autoimmune diseases, and discuss how vitamin D deficiency may contribute to autoimmunity via its effects on the intestinal barrier function, microbiome composition, and/or direct effects on immune responses.

中文翻译：

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维生素D，肠道微生物组和全身自身免疫之间的关系。

人们越来越认识到微生物组在健康和疾病状态中的作用。系统性自身免疫性疾病的微生物组研究在较小程度上显示出炎症性肠病，类风湿性关节炎和系统性红斑狼疮中独特的微生物模式，而没有多发性硬化症的单一缺陷或模式。自身免疫性疾病往往易患维生素D缺乏症，从而改变了微生物组和肠道上皮屏障的完整性。在这篇综述中，我们总结了肠道细菌对免疫系统的影响，探讨了自身免疫疾病研究中出现的微生物模式，并讨论了维生素D缺乏症如何通过其对肠道屏障功能，微生物组组成的影响而有助于自身免疫。 ，