In primary infection with Salmonella, it has been reported-without consideration of Salmonella's functions-that humoral immunity plays no role in the clearance of bacteria. In fact, Salmonella targets and suppresses several aspects of humoral immunity, including B cell lymphopoiesis, B cell activation, and IgG production. In particular, the suppression of IgG-secreting plasma cell maintenance allows the persistence of Salmonella in tissues. Therefore, the critical role(s) of humoral immunity in the response to Salmonella infection, especially at the late phase, should be re-investigated. The suppression of IgG plasma cell memory strongly hinders vaccine development against non-typhoidal Salmonella (NTS) because Salmonella can also reduce humoral immune memory against other bacteria and viruses, obtained from previous vaccination or infection. We propose a new vaccine against Salmonella that would not impair humoral immunity, and which could also be used as a treatment for antibody-dependent autoimmune diseases to deplete pathogenic long-lived plasma cells, by utilizing the Salmonella's own suppression mechanism of humoral immunity.

中文翻译：

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体液免疫与沙门氏菌。

在沙门氏菌的初次感染中，据报道，在不考虑沙门氏菌功能的情况下，体液免疫在清除细菌方面不起作用。实际上，沙门氏菌靶向并抑制体液免疫的几个方面，包括B细胞淋巴细胞生成，B细胞活化和IgG产生。特别是，抑制分泌IgG的浆细胞的维持可使沙门氏菌在组织中持续存在。因此，应重新研究体液免疫在沙门氏菌感染反应中的关键作用，尤其是在晚期。IgG浆细胞记忆的抑制作用强烈阻碍了针对非伤寒沙门氏菌（NTS）的疫苗开发，因为沙门氏菌还可以降低针对其他细菌和病毒的体液免疫记忆，而这些细菌是从先前的疫苗接种或感染获得的。