Parkinson disease is characterized by motor and nonmotor symptoms, reduced striatal dopamine signaling, and loss of dopamine neurons in the substantia nigra. It is now known that the pathological process in Parkinson disease may begin decades before the clinical diagnosis and include a variety of neuronal alterations in addition to the dopamine system.

中文翻译：

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通过体内成像评估帕金森病的突触变化

帕金森病的特征是运动和非运动症状、纹状体多巴胺信号传导减少以及黑质中多巴胺神经元的丧失。现在已知帕金森病的病理过程可能在临床诊断前几十年就开始了，并且除了多巴胺系统之外还包括各种神经元改变。