Molecular Imaging for Cancer Immunotherapy: Seeing Is Believing.,Bioconjugate Chemistry

当前位置： X-MOL 学术 › Bioconjugate Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Molecular Imaging for Cancer Immunotherapy: Seeing Is Believing.
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2020-01-27 , DOI: 10.1021/acs.bioconjchem.9b00851
Madiha Saeed ₁ , Zhiai Xu ₂ , Bruno G De Geest ₃ , Huixiong Xu ₄ , Haijun Yu ₁

Affiliation

The importance of the immune system in cancer therapy has been reaffirmed by the success of the immune checkpoint blockade. The complex tumor microenvironment and its interaction with the immune system, however, remain mysteries. Molecular imaging may shed light on fundamental aspects of the immune response to elucidate the mechanism of cancer immunotherapy. In this review, we discuss various imaging approaches that offer in-depth insight into the tumor microenvironment, checkpoint blockade therapy, and T cell-mediated antitumor immune responses. Recent advances in the molecular imaging modalities, including magnetic resonance imaging (MRI), positron electron tomography (PET), and optical imaging (e.g., fluorescence and intravital imaging) for in situ tracking of the immune response, are discussed. It is envisaged that the integration of imaging with immunotherapy may broaden our understanding to predict a particular antitumor immune response.

中文翻译：

癌症免疫疗法的分子成像：眼见为实。

免疫检查点封锁的成功再次证实了免疫系统在癌症治疗中的重要性。然而，复杂的肿瘤微环境及其与免疫系统的相互作用仍然是个谜。分子成像可能会阐明免疫反应的基本方面，以阐明癌症免疫疗法的机制。在这篇综述中，我们讨论了各种成像方法，可深入了解肿瘤的微环境，检查点阻断疗法以及T细胞介导的抗肿瘤免疫反应。讨论了分子成像模式的最新进展，包括磁共振成像（MRI），正电子电子断层扫描（PET）和光学成像（例如荧光和活体成像），用于就地跟踪免疫反应。

更新日期：2020-01-27

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11