Precisely regulating the ligand exchange on the nanocluster (NC) surface is challenging but important for fully understanding metal-ligand interactions and transformations. In this work, the homosilver nanocluster Ag40(TBBM)22(CH3COO)10 (Ag40) and its Au-substitution derivative AuAg39(TBBM)20(CH3COO)12 (AuAg39) have been synthesized and characterized by single-crystal X-ray crystallography (SC-XRD), nuclear magnetic resonance (NMR), X-ray photoelectron spectroscopy (XPS), and thermogravimetric analysis (TGA). By precisely controlling the template metal exchange progress, the intermediate product, namely, AuAg39(TBBM)21(CH3COO)11 (AuAg39-inter), was also obtained and then characterized by SC-XRD. These three nanoclusters possess a similar metallic framework, albeit some of the thiol ligands of Ag40 have been replaced by the introduced acetate ligands in both AuAg39-inter and AuAg39. Furthermore, Ag40 and AuAg39 NCs can serve as chiral amplifiers for testing the ee values of 2-chloropropionic acid, ibuprofen, naproxen, and isoleucine with high sensitivity.

中文翻译：

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在维持的纳米簇模板中由金取代引起的不同类型的配体交换。

精确调节纳米团簇（NC）表面上的配体交换具有挑战性，但对于充分理解金属-配体的相互作用和转化非常重要。在这项工作中，合成了纯银纳米簇Ag40（TBBM）22（CH3COO）10（Ag40）及其金取代衍生物AuAg39（TBBM）20（CH3COO）12（AuAg39），并通过单晶X射线晶体学对其进行了表征。 （SC-XRD），核磁共振（NMR），X射线光电子能谱（XPS）和热重分析（TGA）。通过精确控制模板金属的交换进程，还获得了中间产物AuAg39（TBBM）21（CH3COO）11（AuAg39-inter），然后通过SC-XRD对其进行了表征。这三个纳米簇具有相似的金属骨架，尽管在AuAg39-inter和AuAg39中，Ag40的某些硫醇配体已被引入的乙酸酯配体取代。此外，Ag40和AuAg39 NC可以用作手性放大器，以高灵敏度测试2-氯丙酸，布洛芬，萘普生和异亮氨酸的ee值。