While rodent cancer models are essential for early proof-of-concept and mechanistic studies for immune therapies, these models have limitations with regards to predicting the ultimate effectiveness of new immunotherapies in humans. As a unique spontaneous, large animal model of cancer, the value of conducting studies in pet dogs with cancer has been increasingly recognized by the research community. This review will therefore summarize key aspects of the dog cancer immunotherapy model and the role that these studies may play in the overall immunotherapy drug research effort. We will focus on cancer types and settings in which the dog model is most likely to impact clinical immuno-oncology research and drug development. Immunological reagent availability is discussed, along with some unique opportunities and challenges associated with the dog immunotherapy model. Overall it is hoped that this review will increase awareness of the dog cancer immunotherapy model and stimulate additional collaborative studies to benefit both man and man's best friend.

中文翻译：

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狗在推进癌症免疫疗法研究中的作用。

虽然啮齿动物癌症模型对于免疫疗法的早期概念验证和机理研究必不可少，但这些模型在预测人类新免疫疗法的最终有效性方面存在局限性。作为一种独特的自发的大型动物癌症模型，对患有癌症的宠物狗进行研究的价值已日益为研究界所认可。因此，本综述将总结犬癌免疫治疗模型的关键方面以及这些研究在整个免疫治疗药物研究工作中可能发挥的作用。我们将关注犬模型最有可能影响临床免疫肿瘤学研究和药物开发的癌症类型和环境。讨论了免疫试剂的可用性，以及与狗免疫疗法模型相关的一些独特机遇和挑战。总的来说，希望这次审查能提高对狗癌免疫疗法模型的认识，并刺激进行更多的合作研究，以造福人类和人类最好的朋友。