Lead, toxic heavy metal of global concern, induces toxicity in various organs via oxidative stress. Thereby, in this study, the protective role of curcumin against lead acetate-induced toxicity was evaluated. Thirty-two male albino rats were allocated equally into four groups and orally administered with corn oil as a vehicle (Cont.), curcumin (CUR) (400 mg/kg bw), lead acetate (LA) (100 mg/kg bw), and lead acetate plus curcumin (LA + CUR). All rats had received their treatments daily for 4 weeks. The results revealed that LA toxicity induced normocytic normochromic anemia with significant leukocytosis and lymphocytosis. Moreover, LA-intoxicated rats showed a marked elevation in the liver enzyme activities, serum cholesterol, and triglyceride levels. In contrast, sero-immunological parameters, total protein, albumin, globulin, and testosterone levels were significantly reduced compared to the control rats. Additionally, LA-induced hepatic and testicular oxidative damage revealed by marked increased in MDA level with prominent reduction in the antioxidant system. The gene expression of the hepatic pro-inflammatory markers and testicular steroidogenic biomarkers including LHR and aromatase were significantly upregulated; meanwhile, the expressions of testicular StAR, CYP17a, 3B-HDS, SR-B1, and P450SCC were significantly downregulated in the LA-intoxicated group. Curcumin treatment could partially improve the hematological, biochemical, and histopathological alterations induced by LA. Also, it was observed that curcumin significantly restored hepatic pro-inflammatory markers and testicular steroidogenic enzymes. In conclusion, curcumin has antioxidant, anti-inflammatory, and immunomodulatory effects and is able to minimize the LA-induced oxidative damage in rats.

中文翻译：

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姜黄素对乙酸铅诱导的大鼠血液生化改变，肝毒性和睾丸氧化损伤的改善作用。

铅是全球关注的有毒重金属，它通过氧化应激在各种器官中引起毒性。因此，在本研究中，评估了姜黄素对乙酸铅诱导的毒性的保护作用。将32只白化病雄性大鼠平均分为四组，口服玉米油作为媒介物（续），姜黄素（CUR）（400 mg / kg体重），乙酸铅（LA）（100 mg / kg体重） ，以及醋酸铅加姜黄素（LA + CUR）。所有大鼠每天接受其治疗4周。结果表明，LA毒性可导致正常血红细胞增多症和淋巴细胞增多的正常血红细胞贫血。此外，LA醉酒的大鼠肝酶活性，血清胆固醇和甘油三酯水平显着升高。相反，血清免疫学参数，总蛋白，白蛋白，球蛋白，与对照组相比，睾丸激素和睾丸激素水平显着降低。此外，LA诱导的肝和睾丸氧化损伤表现为MDA水平显着增加，而抗氧化系统显着降低。肝促炎标志物和睾丸类固醇生物标志物（包括LHR和芳香化酶）的基因表达明显上调；同时，LA中毒组睾丸StAR，CYP17a，3B-HDS，SR-B1和P450SCC的表达明显下调。姜黄素治疗可以部分改善由LA引起的血液学，生化和组织病理学改变。此外，观察到姜黄素可显着恢复肝脏的促炎标记和睾丸类固醇生成酶。总之，姜黄素具有抗氧化，抗炎，