Abstract

Artificial enzymes have provided great antimicrobial activity to combat wound infection. However, the lack of tissue repair capability compromised their treatment effect. Therefore, development of novel artificial enzyme concurrently with the excellent antibacterial activity and the property of promoting wound healing are required. Here, we demonstrated the hydrogel-based artificial enzyme composed of copper and amino acids possessed intrinsic peroxidase-like catalytic activity, which could combat wound pathogen effectively and accelerate wound healing by stimulating angiogenesis and collagen deposition. Furthermore, the system possesses good biocompatibility for practical application. The synergic effect of the hydrogel-based artificial enzyme promises the system as a new paradigm in bacteria-infected wound healing therapy.

中文翻译：

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基于水凝胶的人造酶，用于抵抗细菌和促进伤口愈合

摘要

人造酶提供了强大的抗菌活性，可以对抗伤口感染。但是，缺乏组织修复能力损害了它们的治疗效果。因此，需要同时开发具有优异的抗菌活性和促进伤口愈合的特性的新型人工酶。在这里，我们证明了由铜和氨基酸组成的基于水凝胶的人造酶具有固有的过氧化物酶样催化活性，可以通过刺激血管生成和胶原沉积来有效对抗伤口病原体并加速伤口愈合。此外，该系统具有良好的生物相容性，可用于实际应用。基于水凝胶的人工酶的协同作用使该系统成为细菌感染的伤口愈合疗法的新范例。