Efficient initiation and resolution of inflammation are crucial for wound repair. However, with using tissue adhesives for wound repair, patients occasionally suffered from delayed healing process because slow elimination of those exogenous adhesives generally leads to chronic inflammation. As the demand for minimal invasive therapy continues to rise, desire for adhesive materials that can effectively reconnect surgical gaps and promote wound regeneration becomes increasingly urgent. Herein, by exploiting the inherent porous structure and performance of adhesion to tissue of mesoporous silica nanoparticles (MSNs), we demonstrate a tissue adhesive that can elicit acute inflammatory response and get eliminated after tissue reformation. With formation of nanocomposites in wound gaps, the injured tissues can get reconnected conveniently. The resultant accelerated healing process verify that the strategy of exploiting unique properties of nanomaterials can effectively promote inflammation resolution and wound repair. This design strategy will inspire more innovative tissue adhesives for clinical applications.

中文翻译：

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通过介孔二氧化硅纳米粒子组织粘合剂激活适当的炎症以促进伤口愈合

有效的引发和消除炎症对于伤口修复至关重要。然而，使用组织粘合剂进行伤口修复时，患者有时会遭受愈合过程的延误，因为缓慢清除这些外源性粘合剂通常会导致慢性炎症。随着对微创疗法的需求持续增长，对能够有效地重新连接手术间隙并促进伤口再生的粘合材料的需求变得越来越迫切。在本文中，通过利用固有的多孔结构和介孔二氧化硅纳米粒子（MSNs）对组织的粘附性能，我们证明了一种组织粘合剂，它可以引起急性炎症反应并在组织重塑后被消除。通过在伤口间隙中形成纳米复合材料，可以方便地重新连接受伤的组织。由此产生的加速愈合过程证明，利用纳米材料独特特性的策略可以有效地促进炎症消退和伤口修复。这种设计策略将激发更多创新的组织粘合剂用于临床应用。